Analysis about the influence on the fetus infected with parvovirus B19 using amniotic erythropoietin and troponin-T.

Abstract

OBJECTIVE:

We tried to identify the influence on the fetus infected with parvovirus B19 (PB19) and retrospectively analyze the severity of fetal infection.

METHODS:

Twenty pregnant women who developed maternal PB19 infection were included in this study. A total of 20 amniotic fluid samples were collected for measurement of PB19-DNA, erythropoietin (Epo) and troponin-T (TnT).

RESULTS:

Of the 5 fetuses with hydrops, 2 were rescued by fetal therapy. Significant differences between groups were found for Epo and TnT: Epo 107.1 ± 45.3 mU/ml and TnT 0.040 ± 0.028 ng/ml (mean ± standard deviation) for the symptomatic fetus group; and Epo 18.9 ± 13.7 mU/ml and TnT 0.008 ± 0.014 ng/ml for the asymptomatic fetus group (p = 0.043 for both variables). Setting Epo ≥50 mU/ml as the predictor of disease onset resulted in an Odds ratio of 56.0, with a 95 % confidence interval of 7.68-1,108.76.

CONCLUSION:

The study has determined an amniotic Epo level of ≥50 mU/ml as a factor of the influence on the fetus infected with PB19. The measurement of amniotic Epo level combined with amniotic TnT level is effective for determining the severity of fetal hypoxia.

• Authors: Masashi Yoshida, Hideo Matsuda, Yosuke Yoshinaga, Kazuhiko Asai, Akihiro Kawashima, Kiguna Sei, Miho Horii, Atsushi Nakanishi, Hiroaki Soyama, Kenichi Furuya
• Journal: Archives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 288 Issue 3 Pg. 521-5 (Sep 2013) ISSN: 1432-0711 [Electronic] Germany
• PMID: 23525596 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Troponin T
• Erythropoietin

Topics

• Biomarkers (metabolism)
• Erythropoietin (metabolism)
• Female
• Humans
• Hydrops Fetalis (diagnostic imaging, metabolism, virology)
• Multivariate Analysis
• Parvoviridae Infections (complications, diagnostic imaging, metabolism)
• Parvovirus B19, Human
• Pregnancy
• Pregnancy Complications, Infectious (diagnostic imaging, metabolism)
• Retrospective Studies
• Troponin T (metabolism)
• Ultrasonography