HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Electroacupuncture ameliorates cognitive impairment through inhibition of NF-κB-mediated neuronal cell apoptosis in cerebral ischemia-reperfusion injured rats.

Abstract
Cognitive impairment is a serious mental deficit following stroke that severely affects the quality of life of stroke survivors. Nuclear factor‑κB (NF-κB)-mediated neuronal cell apoptosis is involved in the development of post-stroke cognitive impairment; therefore, it has become a promising target for the treatment of impaired cognition. Acupuncture at the Baihui (DU20) and Shenting (DU24) acupoints is commonly used in China to clinically treat post‑stroke cognitive impairment; however, the precise mechanism of its action is largely unknown. In the present study, we evaluated the therapeutic efficacy of electroacupuncture against post-stroke cognitive impairment and investigated the underlying molecular mechanisms using a rat model of focal cerebral ischemia-reperfusion (I/R) injury. Electroacupuncture at Baihui and Shenting was identified to significantly ameliorate neurological deficits and reduce cerebral infarct volume. Additionally, electroacupuncture improved learning and memory ability in cerebral I/R injured rats, demonstrating its therapeutic efficacy against post-stroke cognitive impairment. Furthermore, electroacupuncture significantly suppressed the I/R-induced activation of NF-κB signaling in ischemic cerebral tissues. The inhibitory effect of electroacupuncture on NF-κB activation led to the inhibition of cerebral cell apoptosis. Finally, electroacupuncture markedly downregulated the expression of pro-apoptotic Bax and Fas, two critical downstream target genes of the NF-κB pathway. Collectively, our findings suggest that inhibition of NF-κB‑mediated neuronal cell apoptosis may be one mechanism via which electroacupuncture at Baihui and Shenting exerts a therapeutic effect on post-stroke cognitive impairment.
AuthorsXiaodong Feng, Shanli Yang, Jiao Liu, Jia Huang, Jun Peng, Jiumao Lin, Jing Tao, Lidian Chen
JournalMolecular medicine reports (Mol Med Rep) Vol. 7 Issue 5 Pg. 1516-22 (May 2013) ISSN: 1791-3004 [Electronic] Greece
PMID23525450 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, CD95
  • NF-kappa B
  • Tnfrsf6 protein, rat
  • bcl-2-Associated X Protein
Topics
  • Acupuncture Points
  • Animals
  • Antigens, CD95 (genetics, metabolism)
  • Apoptosis
  • Brain Ischemia (complications, metabolism, pathology, physiopathology)
  • Cell Nucleus (metabolism)
  • Cerebral Infarction
  • Cognition Disorders (complications, metabolism, pathology, therapy)
  • Down-Regulation
  • Electroacupuncture
  • Male
  • NF-kappa B (metabolism)
  • Neurons (metabolism, pathology)
  • Protein Transport
  • Rats
  • Rats, Sprague-Dawley
  • Reperfusion Injury (complications, metabolism, pathology, physiopathology)
  • Signal Transduction
  • bcl-2-Associated X Protein (genetics, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: