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Treatment of peritoneal carcinomatosis from breast cancer by maximal cytoreduction and HIPEC: a preliminary report on 5 cases.

Abstract
Although peritoneal carcinomatosis from breast cancer is a rare event it frequently causes morbidity and mortality. Current literature provides scarce information on its management. We report outcomes in 5 patients (mean age 59.4 years) with peritoneal carcinomatosis from breast cancer treated with maximal cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) by the closed technique, at 40 °C for 1 h with cisplatin 75 mg/m(2). The primary breast cancer was a ductal carcinoma in 3 patients and a lobular carcinoma in 2. Mean peritoneal cancer index was 20.2. In 4 of the 5 patients surgery achieved macroscopic complete cytoreduction. One patient died of disease at 56 months, 4 are alive and disease-free at 13, 45, 74 and 128 months. These encouraging outcomes suggest that cytoreduction and HIPEC is a promising approach to offer to highly selected patients with peritoneal carcinomatosis from breast cancer and that this approach merit investigation in a larger series.
AuthorsMaurizio Cardi, Paolo Sammartino, Maria Luisa Framarino, Daniele Biacchi, Enrico Cortesi, Simone Sibio, Fabio Accarpio, Claudio Luciani, Antonella Palazzo, Angelo di Giorgio
JournalBreast (Edinburgh, Scotland) (Breast) Vol. 22 Issue 5 Pg. 845-9 (Oct 2013) ISSN: 1532-3080 [Electronic] Netherlands
PMID23523180 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Cisplatin
Topics
  • Aged
  • Antineoplastic Agents (administration & dosage, therapeutic use)
  • Breast Neoplasms (pathology, therapy)
  • Carcinoma, Ductal, Breast (secondary, surgery, therapy)
  • Cisplatin (administration & dosage, therapeutic use)
  • Combined Modality Therapy
  • Female
  • Humans
  • Hyperthermia, Induced
  • Middle Aged
  • Ovarian Neoplasms (secondary, surgery, therapy)
  • Peritoneal Neoplasms (secondary, surgery, therapy)

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