Abstract | INTRODUCTION: OBJECTIVES: We analyze the neurological clinical aspects observed in hypoparathyroidism and correlate them to the biological calcium abnormality and radiological CT scan findings. We also compare these results with data reported in the idiopathic form of striatopallidodentate calcinosis. PATIENTS: The neurological clinical, CT scan findings and outcome have been retrospectively studied in patients recruited during 13 years (2000-2012) for neurological features associated with hypoparathyroidism or pseudohypoparathyroidism. RESULTS: COMMENTS: This study suggests that, in patients with hypoparathyroidism, epilepsy and psychiatric disorders are induced by hypocalcemia and reversible after its correction. Cognitive and extrapyramidal impairment seem to be related to the progressive extension of intracerebral calcification, particularly in patients with a late diagnosis. In patients with pseudohypoparathyroidism, this finding is different because of the contribution of other factors, specific to this disease.
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Authors | H El Otmani, I Lahlou, L Raji, S Omari, Y Belmansour, F Moutaouakil, F-Z Boulaajaj, M Mouden, I Gam, K Hakim, B El Moutawakil, M-A Rafai, H Fadel, I Slassi |
Journal | Revue neurologique
(Rev Neurol (Paris))
2013 Jun-Jul
Vol. 169
Issue 6-7
Pg. 495-501
ISSN: 0035-3787 [Print] France |
Vernacular Title | Calcinose striatopallidodentelée, hypoparathyroïdie et atteinte neurologique: étude de série. |
PMID | 23523016
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Masson SAS. All rights reserved. |
Topics |
- Adolescent
- Adult
- Aged
- Brain Diseases
(diagnostic imaging, epidemiology, etiology)
- Calcinosis
(diagnostic imaging, epidemiology, etiology)
- Cohort Studies
- Corpus Striatum
(diagnostic imaging)
- Female
- Humans
- Hypoparathyroidism
(complications, diagnostic imaging, epidemiology)
- Male
- Middle Aged
- Neuroimaging
(methods)
- Retrospective Studies
- Tomography, X-Ray Computed
- Young Adult
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