Abstract | AIMS: METHODS: RESULTS:
Leptin caused proconvulsant activity in all groups. The administration of AM-251, at a dose of 0.25 μg, increased the frequency of penicillin-induced epileptiform activity by producing status epilepticus-like activity, whereas AM-251, at a dose of 0.125 μg, was not effective when applied alone. ACEA, at a dose of 7.5 μg, decreased the frequency of epileptiform activity. Leptin reversed the anticonvulsant activity of ACEA and enhanced the proconvulsant activity of AM-251. CONCLUSIONS: This study provides electrophysiological evidence that the proconvulsant activity of leptin is mediated, at least in part, by inhibition of cannabinoids in the experimental model of epilepsy.
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Authors | Gokhan Arslan, Sabiha Kubra Alici, Mustafa Ayyildiz, Erdal Agar |
Journal | CNS neuroscience & therapeutics
(CNS Neurosci Ther)
Vol. 19
Issue 4
Pg. 222-8
(Apr 2013)
ISSN: 1755-5949 [Electronic] England |
PMID | 23521910
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Blackwell Publishing Ltd. |
Chemical References |
- Convulsants
- Leptin
- Penicillins
- Piperidines
- Pyrazoles
- Receptor, Cannabinoid, CB1
- AM 251
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Topics |
- Animals
- Convulsants
(administration & dosage, toxicity)
- Epilepsy
(chemically induced, physiopathology)
- Infusions, Intraventricular
- Leptin
(administration & dosage, toxicity)
- Male
- Penicillins
(administration & dosage, toxicity)
- Piperidines
(administration & dosage, toxicity)
- Pyrazoles
(administration & dosage, toxicity)
- Rats
- Rats, Wistar
- Receptor, Cannabinoid, CB1
(agonists, antagonists & inhibitors, physiology)
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