Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention.

Abstract

Association of obesity risk alleles of single nucleotide polymorphisms (SNPs) near or in the SH2B adaptor protein 1 gene (SH2B1) and increased body mass index (BMI) has been often described. A gene in close proximity, apolipoprotein B48 receptor gene (APOB48R), is tagged by the same SNP(s).We analyzed 454 overweight and obese children and adolescents (10.8±2.6 years, BMI-SDS 2.4±0.5; 55% girls) who completed a 1-year lifestyle intervention ('Obeldicks' program). Carriers of obesity risk alleles of non-synonymous SNPs in SH2B1 (rs7498665, Thr484Ala) or APOB48R (rs180743, Pro419Ala), as genotyped by TaqMan, were analysed for changes in anthropometrics (body-mass index (BMI), and standardized BMI (BMI-SDS)), blood pressure (systolic and diastolic) and plasma parameters (total cholesterol, LDL-cholesterol, HDL-cholesterol, triacylglycerides, glucose, insulin, and HOMA).We observed no evidence for an association of the obesity risk alleles to alterations in any of the analyzed phenotypes. Both mean BMI and BMI-SDS improved during the intervention independent of genotype. The mean systolic blood pressure was lowered and concentrations of HDL-cholesterol increased significantly.The obesity risk alleles of non-synonymous SNPs at SH2B1 and APOB48R have no strong effect on weight loss-related phenotypes in overweight children after a 1-year lifestyle intervention.

• Authors: A-L Volckmar, C Pütter, J-Y Song, J Graniger, N Knoll, B Wolters, J Hebebrand, A Scherag, T Reinehr, A Hinney
• Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association (Exp Clin Endocrinol Diabetes) Vol. 121 Issue 6 Pg. 334-7 (Jun 2013) ISSN: 1439-3646 [Electronic] Germany
• PMID: 23519644 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Adaptor Proteins, Signal Transducing
• Blood Glucose
• Cholesterol, LDL
• Insulin
• Receptors, Lipoprotein
• SH2B1 protein, human
• Triglycerides

Topics

• Adaptor Proteins, Signal Transducing (blood, genetics)
• Adolescent
• Alleles
• Blood Glucose (metabolism)
• Blood Pressure
• Body Mass Index
• Child
• Cholesterol, LDL (blood)
• Female
• Humans
• Insulin (blood)
• Male
• Obesity (blood, genetics, physiopathology)
• Polymorphism, Single Nucleotide
• Receptors, Lipoprotein (blood, genetics)
• Risk Factors
• Triglycerides (blood)