Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders.

Burkholderia pseudomallei is the causative agent of the disease melioidosis, which is prevalent in tropical countries and is intractable to a number of antibiotics. In this study, the antibiotic co-trimoxazole (trimethoprim/sulfamethoxazole) was assessed for the post-exposure prophylaxis of experimental infection in mice with B. pseudomallei and its close phylogenetic relative Burkholderia mallei, the causative agent of glanders. Co-trimoxazole was effective against an inhalational infection with B. pseudomallei or B. mallei. However, oral co-trimoxazole delivered twice daily did not eradicate infection when administered from 6h post exposure for 14 days or 21 days, since infected and antibiotic-treated mice succumbed to infection following relapse or immunosuppression. These data highlight the utility of co-trimoxazole for prophylaxis both of B. pseudomallei and B. mallei and the need for new approaches for the treatment of persistent bacterial infection.
AuthorsKay B Barnes, Jackie Steward, Joanne E Thwaite, M Stephen Lever, Carwyn H Davies, Stuart J Armstrong, Thomas R Laws, Neil Roughley, Sarah V Harding, Timothy P Atkins, Andrew J H Simpson, Helen S Atkins
JournalInternational journal of antimicrobial agents (Int J Antimicrob Agents) Vol. 41 Issue 6 Pg. 552-7 (Jun 2013) ISSN: 1872-7913 [Electronic] Netherlands
PMID23517714 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCrown Copyright © 2013. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Administration, Oral
  • Animals
  • Anti-Bacterial Agents (administration & dosage)
  • Burkholderia mallei (drug effects)
  • Burkholderia pseudomallei (drug effects)
  • Chemoprevention (methods)
  • Disease Models, Animal
  • Female
  • Glanders (prevention & control)
  • Inhalation Exposure (prevention & control)
  • Melioidosis (prevention & control)
  • Mice
  • Mice, Inbred BALB C
  • Post-Exposure Prophylaxis (methods)
  • Treatment Outcome
  • Trimethoprim, Sulfamethoxazole Drug Combination (administration & dosage)

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