Abstract |
Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including antiinflammatory, antioxidant, anti- cancer, anti- anaphylaxis effects and against aging. However, the application of QC in pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability. Enhanced bioavailability of QC in the near future is likely to bring this product to the forefront of therapeutic agents for treatment of human disease.
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Authors | X Cai, Z Fang, J Dou, A Yu, G Zhai |
Journal | Current medicinal chemistry
(Curr Med Chem)
Vol. 20
Issue 20
Pg. 2572-82
( 2013)
ISSN: 1875-533X [Electronic] United Arab Emirates |
PMID | 23514412
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Biocompatible Materials
- Drug Carriers
- Liposomes
- Micelles
- Prodrugs
- Quercetin
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Topics |
- Biocompatible Materials
(chemistry)
- Biological Availability
- Drug Carriers
(chemistry)
- Half-Life
- Humans
- Liposomes
(chemistry)
- Micelles
- Nanoparticles
(chemistry)
- Prodrugs
(chemistry, pharmacokinetics)
- Quercetin
(chemistry, pharmacokinetics)
- Solubility
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