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Zephgrabetaine: a new betaine-type amaryllidaceae alkaloid from Zephyranthes grandiflora.

Abstract
Zephgrabetaine (1), a new betaine type Amaryllidaceae alkaloid, along with seven known alkaloids, lycorine, galanthine, lycoramine, hamayne, haemanthamine, tortuosine, and ungeremine were isolated from the bulbs of Zephyranthes grandiflora and their structures elucidated by spectroscopic data analysis. The isolated alkaloids were tested for in vitro cytotoxic activities against two cell lines, C-6 (rat glioma cells) and CHO-K1 (Chinese hamster ovary cells). A dose dependent cytotoxic effect was exhibited by all the alkaloids on these two cancer cell lines with prominent activity of lycorine and haemanthamine.
AuthorsDeepali Katoch, Dharmesh Kumar, Upendra Sharma, Neeraj Kumar, Yogendra S Padwad, Brij Lal, Bikram Singh
JournalNatural product communications (Nat Prod Commun) Vol. 8 Issue 2 Pg. 161-4 (Feb 2013) ISSN: 1934-578X [Print] United States
PMID23513717 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amaryllidaceae Alkaloids
  • zephgrabetaine
  • Betaine
Topics
  • Amaryllidaceae Alkaloids (chemistry, isolation & purification, pharmacology)
  • Animals
  • Betaine (analogs & derivatives, chemistry, isolation & purification, pharmacology)
  • Cell Line, Tumor
  • Cell Survival (drug effects)
  • Cricetinae
  • Liliaceae (chemistry)
  • Magnetic Resonance Spectroscopy
  • Mesocricetus
  • Rats
  • Structure-Activity Relationship

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