Abstract | BACKGROUND: Women with a personal history of breast cancer ( PHBC) have increased risk of an interval cancer. We aimed to identify risk factors for second (ipsilateral or contralateral) screen-detected or interval breast cancer within 1 year of screening in PHBC women. METHODS: RESULTS: There were 697 second breast cancers, of these 240 were interval cancers, among 67,819 screens in 20,941 women. In separate models for women with DCIS or invasive first cancer, first breast cancer surgery predicted all three second breast cancer outcomes (P < 0.001), and high ORs for second breast cancers (between 1.95 and 4.82) were estimated for breast conservation without radiation (relative to mastectomy). In women with invasive first breast cancer, additional variables predicted risk (P < 0.05) for at least one of the three outcomes: first-degree family history, dense breasts, longer time between mammograms, young age at first breast cancer, first breast cancer stage, and adjuvant systemic therapy for first breast cancer; and risk of interval invasive breast cancer was highest in women <40 years at first breast cancer (OR, 3.41; 1.34-8.70), those with extremely dense breasts (OR, 2.55; 1.4-4.67), and those treated with breast conservation without radiation (OR, 2.67; 1.53-4.65). CONCLUSION: IMPACT: Our findings may guide discussion and evaluations of tailored breast screening in PHBC women, and incorporating this information into clinical decision-making warrants further research.
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Authors | Nehmat Houssami, Linn A Abraham, Karla Kerlikowske, Diana S M Buist, Les Irwig, Janie Lee, Diana L Miglioretti |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 22
Issue 5
Pg. 946-61
(May 2013)
ISSN: 1538-7755 [Electronic] United States |
PMID | 23513042
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
(diagnostic imaging, epidemiology, pathology, surgery)
- Early Detection of Cancer
- Female
- Humans
- Mammography
(methods, statistics & numerical data)
- Mass Screening
(methods, statistics & numerical data)
- Middle Aged
- Risk Factors
- United States
(epidemiology)
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