Abstract | OBJECTIVE: DESIGN AND METHODS: Sixty four subjects assigned to 14 weeks of 15 g day(-1) of PGX or placebo were assessed in a randomized, double-blind, placebo-controlled, parallel group trial. At week 0 and 14, primary outcome measures were serum lipids, abdominal adiposity, glucose tolerance and blood pressure. RESULTS: Total and LDL cholesterol were reduced at week 14 with PGX but not placebo (P < 0.05). The reduction in waist circumference at week 14 was greater with PGX versus placebo (P < 0.05). In females, abdominal visceral fat was decreased to a greater extent with PGX versus placebo (P < 0.05). While glucose tolerance worsened with placebo over time, PGX reduced glucose total area under the curve from week 0 to 6 (P = 0.039). Serum concentrations of resistin and IL6 increased slightly in placebo and decreased slightly with PGX . CONCLUSIONS:
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Authors | Raylene A Reimer, Hideyo Yamaguchi, Lindsay K Eller, Michael R Lyon, Roland J Gahler, Veronica Kacinik, Prateek Juneja, Simon Wood |
Journal | Obesity (Silver Spring, Md.)
(Obesity (Silver Spring))
Vol. 21
Issue 9
Pg. E379-87
(Sep 2013)
ISSN: 1930-739X [Electronic] United States |
PMID | 23512917
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 The Obesity Society. |
Chemical References |
- Blood Glucose
- Cholesterol, LDL
- Dietary Fiber
- Hypoglycemic Agents
- Hypolipidemic Agents
- Interleukin-6
- Polysaccharides
- Resistin
- Cholesterol
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Topics |
- Adiposity
- Adult
- Aged
- Asian People
- Blood Glucose
(metabolism)
- Cholesterol
(blood)
- Cholesterol, LDL
(blood)
- Dietary Fiber
(pharmacology, therapeutic use)
- Double-Blind Method
- Female
- Glucose Intolerance
(blood, etiology, prevention & control)
- Humans
- Hypoglycemic Agents
(pharmacology, therapeutic use)
- Hypolipidemic Agents
(pharmacology, therapeutic use)
- Interleukin-6
(blood)
- Intra-Abdominal Fat
(metabolism)
- Male
- Metabolic Syndrome
(etiology, metabolism, prevention & control)
- Middle Aged
- Obesity, Abdominal
(diet therapy, metabolism)
- Polysaccharides
(pharmacology, therapeutic use)
- Resistin
(blood)
- Sex Factors
- Viscosity
- Waist Circumference
- Young Adult
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