Angioplasty and stenting of intracranial atherosclerosis with the Wingspan system: 1-year clinical and radiological outcome in a single Asian center.

Abstract

BACKGROUND:

This study aimed to evaluate the 1-year clinical and angiographic outcome of angioplasty and stenting of intracranial atherosclerosis using Wingspan and Gateway system.

METHODS:

In this prospective study, patients with symptomatic lesions were treated and followed clinically and angiographically by digital subtraction angiography (DSA) for 1 year. The two primary endpoints were recurrent ipsilateral ischemic stroke and in-stent restenosis (ISR) at 1 year. Secondary endpoints included periprocedural death or stroke and all strokes at 1 year. Potential factors correlated with ISR were studied using univariate and multivariate analysis.

RESULTS:

Treatment was attempted in 65 patients and successfully completed in 61 (93.8%). Fifty-nine patients (44 men, 15 women) aged 62.86 ± 11.38 years with 66 stenoses (average degree of stenosis 71.78 ± 11.23%) underwent clinical and DSA follow-up at 1 year. There were 66 stenotic lesions. ISR occurred in 11 of the 66 lesions (16.7%). Luminal gain occurred in 32 of the lesions (48.5%), an unchanged lumen in 4 (6%) and luminal loss in 30 (45.4%). The periprocedural stroke or death rate was 6.1% (4/65), including three hemorrhagic and one ischemic stroke, all of which occurred at the corresponding site and resulted in death. There were no interval strokes between the periprocedural time and the 1-year follow-up. The occurrence of ISR was correlated with the degree of stenosis before treatment and was not correlated with patient age or sex, vessel diameter, location of stenosis or failure to control risk factors for atherosclerosis.

CONCLUSIONS:

One-year clinical and angiographic outcomes of angioplasty and stenting are promising for symptomatic intracranial atherosclerosis.

• Authors: Simon Chun Ho Yu, Thomas Wai Hong Leung, Kwok Tung Lee, Lawrence Ka Sing Wong
• Journal: Journal of neurointerventional surgery (J Neurointerv Surg) Vol. 6 Issue 2 Pg. 96-102 (Mar 2014) ISSN: 1759-8486 [Electronic] England
• PMID: 23512176 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Aged
• Angioplasty (methods)
• Female
• Follow-Up Studies
• Hong Kong (epidemiology)
• Humans
• Intracranial Arteriosclerosis (diagnostic imaging, epidemiology, therapy)
• Male
• Middle Aged
• Radiography
• Stents
• Time Factors
• Treatment Outcome