Abstract | OBJECTIVE: STUDY DESIGN: 239 women, ginger (n=116) and placebo (n=123), who underwent elective cesarean section at term under combined spinal- epidural anesthesia were provided with standard preoperative antiemetic treatment in addition to a randomized study drug. They were given two capsules (1g each) of either dry powdered ginger or placebo, one capsule a half-hour before induction of anesthesia and the second 2h after surgery. The study was double-blinded and the incidences of nausea and vomiting were assessed both intraoperatively and postoperatively. Levels of pain and pruritus were also assessed postoperatively. RESULTS: The intraoperative incidence of nausea was 52% and 61%, ginger versus placebo (p=0.149). The number of episodes of intraoperative nausea was less in the ginger group compared to placebo (mean difference was -0.396, 95% CI -0.738, -0.054) and the result was statistically significant (p=0.023). The incidence of intraoperative vomiting was 27.35% in the ginger group and 36.59% in the placebo group, and the difference was not statistically significant (p=0.126). The number of episodes of vomiting during surgery was less in the ginger group compared to placebo: (mean difference -0.158, 95% CI -0.626, 0.311) although statistically insignificant (p=0.505). Furthermore, postoperatively, there was no statistical difference in the incidence of nausea and vomiting assessed at 0, 2, 2 ½ and 24h after surgery. There were also no differences in postoperative pain or pruritus. CONCLUSION:
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Authors | Arun Kalava, Sandip J Darji, Allison Kalstein, Joel M Yarmush, Joseph SchianodiCola, Jonathan Weinberg |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 169
Issue 2
Pg. 184-8
(Jul 2013)
ISSN: 1872-7654 [Electronic] Ireland |
PMID | 23510951
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Anesthesia, Conduction
(adverse effects)
- Cesarean Section
(adverse effects)
- Double-Blind Method
- Elective Surgical Procedures
(adverse effects)
- Female
- Ginger
- Humans
- Intraoperative Complications
(etiology, prevention & control)
- Middle Aged
- Phytotherapy
- Plant Preparations
(administration & dosage)
- Postoperative Nausea and Vomiting
(etiology, prevention & control)
- Pregnancy
- Prospective Studies
- Treatment Outcome
- Young Adult
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