Abstract | OBJECTIVES: METHODS: From a total of 2066 participants from the Atherosclerosis Risk In Communities Carotid MRI study, 1496 were included for this analysis. Wall Thickness and Lipid core presence were measured using gadolinium-enhanced MRI. Blood lactate was categorized into quartiles (Q1: <5.9 mg/dl, Q2: 5.9-7.2 mg/dl, Q3: 7.3-9.2 mg/dl, and Q4: >9.2 mg/dl). RESULTS: Of the 1496 study participants, 763 (51%) were females, 296 (19.8%) African American, 539 (36%) obese and 308 (20.6%) had diabetes. There was a strong and graded association between lactate and wall thickness [Q1: 1.08 mm (95% CI: 1.01 mm-1.15 mm), Q2: 1.33 mm (95% CI: 1.19 mm-1.47 mm), Q3: 1.44 (95% CI: 1.34 mm-1.54 mm) and Q4: 1.62 (95% CI: 1.53 mm-1.71 mm); p for trend <0.001] after adjusting for age, gender, ethnicity, stature, body mass index (BMI), waist circumference, LDL, High sensitivity C reactive protein ( HsCRP), statin use, thiazolidinedione use, hypertension, and diabetes. This association was attenuated, but still significant, after adjusting for a marker of insulin resistance, the triglyceride/HDL ratio, [Q1: 0.96 mm (95% CI: 0.82 mm-1.10 mm), Q2: 1.17 mm (95% CI: 1.08 mm-1.26 mm), Q3: 1.18 mm (95% CI: 1.07 mm-1.29 mm), Q4: 1.22 mm (95% CI: 1.13 mm-1.31 mm), p for linear trend 0.039]. There was no association of lactate with lipid core presence after adjustment for wall thickness. CONCLUSIONS:
|
Authors | Ghanshyam Palamaner Subash Shantha, Bruce Wasserman, Brad C Astor, Josef Coresh, Fredrick Brancati, A Richey Sharrett, J Hunter Young |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 228
Issue 1
Pg. 249-55
(May 2013)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 23510829
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Copyright | Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Cholesterol, HDL
- Triglycerides
- Lactic Acid
- Gadolinium
|
Topics |
- Aged
- Biomarkers
(blood)
- Carotid Artery Diseases
(blood, epidemiology, pathology)
- Cholesterol, HDL
(blood)
- Female
- Gadolinium
- Humans
- Insulin Resistance
- Lactic Acid
(blood)
- Magnetic Resonance Angiography
(methods)
- Male
- Residence Characteristics
- Risk Factors
- Triglycerides
(blood)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|