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[A case of locally advanced sigmoid colon cancer curatively resected after neoadjuvant chemotherapy with FOLFIRI plus panitumumab].

Abstract
A 72-year-old woman having abdominal pain and high fever was diagnosed with KRAS wild-type sigmoid colon cancer, invading the urinary bladder and uterus with a pelvic abscess. Considering the difficulty of curative resection, we first performed sigmoid colostomy and abscess drainage. Remarkable tumor regression was indicated by CT and colonoscopy after 1 course of FOLFIRI and 5 courses of FOLFIRI+panitumumab. Following an additional 2 courses of panitumumab, sigmoidectomy and partialcystectomy were performed. Six courses of FOLFIRI+panitumumab were administered postoperatively and no recurrence has been observed for 7 months. FOLFIRI+panitumumab may be an effective preoperative chemotherapy for patients with KRAS wild-type locally advanced colon cancer.
AuthorsKohei Horioka, Keizo Kaku, Sei-ichirou Jimi, Yoshihiro Oohata, Takafumi Kamei
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 3 Pg. 397-9 (Mar 2013) ISSN: 0385-0684 [Print] Japan
PMID23507607 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • KRAS protein, human
  • Proto-Oncogene Proteins
  • Panitumumab
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins
  • Leucovorin
  • Fluorouracil
  • Camptothecin
Topics
  • Antibodies, Monoclonal (administration & dosage)
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Camptothecin (administration & dosage, analogs & derivatives)
  • Female
  • Fluorouracil (administration & dosage)
  • Humans
  • Leucovorin (administration & dosage)
  • Middle Aged
  • Neoadjuvant Therapy
  • Neoplasm Invasiveness
  • Panitumumab
  • Proto-Oncogene Proteins (genetics)
  • Proto-Oncogene Proteins p21(ras)
  • Sigmoid Neoplasms (drug therapy, genetics, surgery)
  • ras Proteins (genetics)

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