Analysis of the effect of breast magnetic resonance imaging on the outcome in women undergoing breast conservation surgery with radiation therapy.

Abstract

BACKGROUND:

It remains uncertain whether MRI identification of additional foci of disease leads to improved outcome. We undertook a study to evaluate the influence of breast MRI on early and long-term outcome.

METHODS:

Among 1,271 patients undergone breast cancer surgery between January 2005 and December 2006, 785 patients were attempted for BCS. Operative approach and radiologic findings were compared according to MRI use. We reselected 615 patients with unilateral early-stage breast cancer treated with BCS including RT. We compared the histopathologic characteristics and outcomes according to MRI use.

RESULTS:

In patients attempted for BCS (n = 785), re-excision rates were not significantly different according to MRI use (P = 1.000). Conversion to mastectomy or bilateral cancer surgery were higher in MRI group (P = 0.002). The IBTR rate was higher in the non-MRI group (P = 0.020). Difference in contralateral cancer rate and total recurrence rates failed to reach statistical significance (P = 0.168, 0.383, respectively). Multivariate study after adjustment showed no difference in recurrence rates and IBTR rates between the two groups (hazard ratios 1.34, 6.37 Ps = 0.385, 0.076).

CONCLUSION:

Use of MRI in patients with early-stage breast cancer did not result in improvement of a patient's outcome.

• Authors: Eun Sook Ko, Boo-Kyung Han, Rock Bum Kim, Eun Young Ko, Jung Hee Shin, Sang Yu Nam, Meeyoung Nam, Seok Jin Nam, Jeong Eon Lee, Won Ho Kil, Se-Kyung Lee
• Journal: Journal of surgical oncology (J Surg Oncol) Vol. 107 Issue 8 Pg. 815-21 (Jun 2013) ISSN: 1096-9098 [Electronic] United States
• PMID: 23505028 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2013 Wiley Periodicals, Inc.

Chemical References

• Biomarkers, Tumor

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (analysis)
• Breast Neoplasms (diagnosis, epidemiology, pathology, radiotherapy, surgery)
• Chemotherapy, Adjuvant
• Conversion to Open Surgery (statistics & numerical data)
• Female
• Humans
• Magnetic Resonance Imaging
• Mastectomy, Segmental
• Middle Aged
• Multivariate Analysis
• Neoplasm Recurrence, Local (diagnosis, epidemiology)
• Neoplasm Staging
• Odds Ratio
• Radiotherapy, Adjuvant
• Republic of Korea (epidemiology)
• Time Factors
• Treatment Outcome