Abstract | BACKGROUND: Human papillomavirus (HPV) is causally implicated in a subset of cancers of the upper aero-digestive tract (UADT). METHODS: Associations between type-specific HPV antibodies were examined among 1496 UADT cancer case subjects and 1425 control subjects by estimating odds ratios ( ORs) in logistic regression analyses adjusted for potential confounders. The agreement between serology and tumor markers of HPV infection, including presence of HPV DNA and p16 expression, were examined in a subset of tumors. RESULTS: HPV16 L1 seropositivity was associated with increased risk of oral cavity and oropharyngeal cancer (OR = 1.94, 95% confidence interval [CI] = 1.03 to 3.65; OR = 8.60, 95% CI = 5.21 to 14.20, respectively). HPV16 E6 antibodies were present in 30.2% of oropharyngeal case subjects and only 0.8% of control subjects (OR = 132.0, 95% CI = 65.29 to 266.86). Combined seropositivity to HPV16 E6 and E7 was rare (n = 1 of 1425 control subjects). An agreement of 67% was observed between HPV16 E6 serology and the corresponding presence of an HPV-related cancer: four of six HPV DNA-positive/p16-overexpressing tumors were HPV16 E6 antibody positive. An HPV16 independent association was observed for HPV18 and oropharyngeal cancer (OR = 8.14, 95% CI = 2.21 to 29.99 for HPV18 E6 seropositivity) and HPV6 and laryngeal cancer (OR = 3.25, 95% CI = 1.46 to 7.24 for HPV6 E7 seropositivity). CONCLUSIONS:
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Authors | Devasena Anantharaman, Tarik Gheit, Tim Waterboer, Behnoush Abedi-Ardekani, Christine Carreira, Sandrine McKay-Chopin, Valerie Gaborieau, Manuela Marron, Pagona Lagiou, Wolfgang Ahrens, Ivana Holcátová, Franco Merletti, Kristina Kjaerheim, Renato Talamini, Lorenzo Simonato, Xavier Castellsague, Tatiana V Macfarlane, Anne-Marie Biggs, Nalin Thakker, Ariana Znaor, Peter Thomson, Cristina Canova, David I Conway, Claire M Healy, Massimo Tommasino, Michael Pawlita, Paul Brennan |
Journal | Journal of the National Cancer Institute
(J Natl Cancer Inst)
Vol. 105
Issue 8
Pg. 536-45
(Apr 17 2013)
ISSN: 1460-2105 [Electronic] United States |
PMID | 23503618
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Viral
- Biomarkers, Tumor
- DNA, Viral
- E6 protein, Human papillomavirus type 16
- Oncogene Proteins, Viral
- Papillomavirus E7 Proteins
- Repressor Proteins
- oncogene protein E7, Human papillomavirus type 16
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Topics |
- Aged
- Antibodies, Viral
(isolation & purification)
- Biomarkers, Tumor
(immunology)
- Case-Control Studies
- DNA, Viral
(isolation & purification)
- Female
- Fluorescent Antibody Technique
- Human papillomavirus 16
(genetics, immunology, isolation & purification)
- Humans
- Laryngeal Neoplasms
(pathology, virology)
- Logistic Models
- Male
- Middle Aged
- Neoplasm Staging
- Odds Ratio
- Oncogene Proteins, Viral
(immunology)
- Oropharyngeal Neoplasms
(pathology, virology)
- Papillomavirus E7 Proteins
(immunology)
- Papillomavirus Infections
(complications, virology)
- Polymerase Chain Reaction
(methods)
- Repressor Proteins
(immunology)
- Up-Regulation
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