Blonanserin, an antipsychotic and dopamine D₂/D₃receptor antagonist, and ameliorated alcohol dependence.

Abstract

Blonanserin (BNS) is used for treatment of both positive and negative symptoms of schizophrenia in Japan and Korea. Because BNS has weak α1 receptor blocking activities and is almost devoid of histamine H1 and muscarinic M1 antagonist activity, BNS is better tolerated than other atypical antipsychotics. A high degree of D₃ receptor blockage is reported to be predictive of drug abuse and alcoholism, and BNS has strong D₃ receptor antagonism. Thus, BNS may be useful in the treatment of alcoholism. We present a case in which BNS ameliorated alcohol dependence.

• Authors: Manabu Takaki, Hiroshi Ujike
• Journal: Clinical neuropharmacology (Clin Neuropharmacol) 2013 Mar-Apr Vol. 36 Issue 2 Pg. 68-9 ISSN: 1537-162X [Electronic] United States
• PMID: 23503552 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• Dopamine Antagonists
• Dopamine D2 Receptor Antagonists
• Piperazines
• Piperidines
• Receptors, Dopamine D2
• Receptors, Dopamine D3
• blonanserin

Topics

• Adult
• Alcoholism (diagnosis, drug therapy, psychology)
• Antipsychotic Agents (therapeutic use)
• Dopamine Antagonists (pharmacology, therapeutic use)
• Dopamine D2 Receptor Antagonists
• Female
• Humans
• Piperazines (therapeutic use)
• Piperidines (therapeutic use)
• Receptors, Dopamine D2 (physiology)
• Receptors, Dopamine D3 (antagonists & inhibitors, physiology)