A composite neoplastic lesion of the vulva with mixed features of fibroadenoma and hidradenoma papilliferum combined with pseudoangiomatous stromal hyperplasia containing multinucleated giant cells.

Abstract

Anogenital mammary-like glands (AGMLG) are nowadays considered a normal component of the anogenital area. Lesions affecting AGMLG are similar to those seen in breast. We present a case of a complex neoplastic lesion of the AGMLG with mixed features of fibroadenoma and hidradenoma papilliferum combined with pseudoangiomatous stromal hyperplasia. Multinucleated cells were detected in the pseudoangiomatous stromal hyperplasia areas as seen in some patients with neurofibromatosis type 1. The neoplasm is similar to rare mammary composite neoplasms that feature simultaneously patterns of a fibroepithelial neoplasms and intraductal papilloma.

• Authors: Anastasia M Konstantinova, Denisa Kacerovska, Michal Michal, Dmitry V Kazakov
• Journal: The American Journal of dermatopathology (Am J Dermatopathol) Vol. 36 Issue 10 Pg. e171-4 (Oct 2014) ISSN: 1533-0311 [Electronic] United States
• PMID: 23503319 (Publication Type: Case Reports, Journal Article)

Topics

• Acrospiroma (pathology)
• Angiomatosis (pathology)
• Breast Diseases (pathology)
• Female
• Fibroadenoma (pathology)
• Giant Cells (pathology)
• Humans
• Hyperplasia (pathology)
• Middle Aged
• Neoplasms, Complex and Mixed (pathology)
• Sweat Gland Neoplasms (pathology)
• Vulvar Neoplasms (pathology)