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Study of glycol chitosan-carboxymethyl β-cyclodextrins as anticancer drugs carrier.

Abstract
Efficient target delivery system for insoluble anticancer drugs to increase the intracellular drug concentration has become a focus in cancer therapy. Herein, glycol chitosan-carboxymethyl β-cyclodextrins (G-chitosan-CM-dextrins) was synthesized for delivering different hydrophobic anticancer drugs. Surface plasmon resonance and UV-vis spectroscopy results showed that all the three anticancer drugs (5-fluorouracil, doxorubicin, and vinblastine) could be successfully loaded into the cavities of the covalently linked CM-dextrins. Moreover, the free carboxymethyl groups could enhance the binding interactions between the covalently linked CM-dextrins and anticancer drugs. Release behaviors with pH changes of the three drugs were also explored, result showed different drugs would be released by different ways, as for doxorubicin, pH sensitive release has been realized. The obtained G-chitosan-CM-dextrins carrier has both mucoadhesive property of G-chitosan and hydrophobic cavities of β-cyclodextrins. Therefore, the new synthesized G-chitosan-CM-dextrins carrier exhibits a promising potential capability for anticancer drug delivery in tumor therapy.
AuthorsHaina Tan, Fei Qin, Dongfeng Chen, Songbai Han, Wu Lu, Xin Yao
JournalCarbohydrate polymers (Carbohydr Polym) Vol. 93 Issue 2 Pg. 679-85 (Apr 02 2013) ISSN: 1879-1344 [Electronic] England
PMID23499111 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Drug Carriers
  • beta-Cyclodextrins
  • carboxymethyl-beta-cyclodextrin
  • glycol-chitosan
  • Vinblastine
  • Doxorubicin
  • Chitosan
  • Fluorouracil
Topics
  • Antineoplastic Agents (administration & dosage, chemistry)
  • Chitosan (chemistry)
  • Doxorubicin (administration & dosage)
  • Drug Carriers (analysis, chemistry)
  • Fluorouracil (administration & dosage)
  • Hydrogen-Ion Concentration
  • Hydrophobic and Hydrophilic Interactions
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Surface Plasmon Resonance
  • Vinblastine (administration & dosage)
  • beta-Cyclodextrins (chemistry)

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