Clearance of phenylethylmalonamide during haemodialysis of a patient with renal failure.

Abstract

Information is presented for the serum concentrations during haemodialysis of primidone, phenobarbitone, and phenylethylmalonamide (PEMA) in a patient with renal failure receiving chronic primidone therapy. The concentrations of drug and metabolites fell during haemodialysis, but PEMA concentrations were above normal at all times. The average renal clearance of PEMA during 6 h of dialysis was found to be 84.7 +/- 4.6 ml min-1.

• Authors: J M Streete, D J Berry, J A Jones, M J Groggin
• Journal: Therapeutic drug monitoring (Ther Drug Monit) Vol. 12 Issue 3 Pg. 281-3 (May 1990) ISSN: 0163-4356 [Print] United States
• PMID: 2349613 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Malonates
• Primidone
• Phenylethylmalonamide
• Phenobarbital

Topics

• Humans
• Kidney Failure, Chronic (blood)
• Male
• Malonates (pharmacokinetics)
• Middle Aged
• Phenobarbital (blood, pharmacokinetics)
• Phenylethylmalonamide (blood, pharmacokinetics)
• Primidone (blood, pharmacokinetics)
• Renal Dialysis
• Time Factors