Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke.

Abstract

We investigated 32 patients with completed ischemic stroke less than or equal to 6 hours after the onset of symptoms by means of computed tomography, cerebral angiography, and technetium-99m-labeled hexamethylpropyleneamine oxime single-photon emission computed tomography to study cerebral blood flow. Follow-up computed tomography and cerebral blood flow studies were performed 1 week and 1 month after admission. Poor outcome at 1 month was evident in 18 (78%) of the 23 patients with severe neurologic deficit on admission and in 11 (92%) of the 12 patients with severe hypoperfusion in the affected hemisphere on admission. All 10 patients with severe impairment of both neurologic status and cerebral blood flow had a poor outcome at 1 month. We detected severe hypoperfusion in patients with large lesions on computed tomograms or cerebral artery occlusions on angiograms. Cerebral blood flow had increased at the 1-week follow-up despite different clinical outcomes. Our data provide evidence that early evaluation of cerebral blood flow with single-photon emission computed tomography is useful to detect subgroups of patients with different clinical outcomes during the acute phase of ischemic stroke.

• Authors: F Giubilei, G L Lenzi, V Di Piero, C Pozzilli, P Pantano, S Bastianello, C Argentino, C Fieschi
• Journal: Stroke (Stroke) Vol. 21 Issue 6 Pg. 895-900 (Jun 1990) ISSN: 0039-2499 [Print] United States
• PMID: 2349593 (Publication Type: Journal Article)

Topics

• Brain Ischemia (complications, diagnostic imaging, pathology, physiopathology)
• Cerebrovascular Circulation
• Female
• Humans
• Male
• Neurologic Examination
• Predictive Value of Tests
• Prognosis
• Time Factors
• Tomography, Emission-Computed, Single-Photon