A pilot study of oxaliplatin with oral S-1 as second-line chemotherapy for patients with recurrent adenocarcimona of the uterine cervix.

Abstract

BACKGROUND:

The efficacy and safety of S-1/oxaliplatin (SOX) therapy in patients with recurrent adenocarcinoma of the uterine cervix were examined in a pilot study.

PATIENTS AND METHODS:

S-1 was orally administered for 14 days at a dose of 80-120 mg/body/day to 7 patients with recurrent adenocarcinoma of the uterine cervix, with oxaliplatin being administered intravenously at a dose of 100 mg/m(2) on day 1. Each therapy cycle was 21 days, and the patients received 6 cycles at most. The antitumor effect, adverse events, progression-free survival (PFS), and overall survival (OS) were investigated.

RESULTS:

The median age of the patients was 49 years. The antitumor effect was rated as a complete response in 2 patients, partial response in 2, and stable disease in 3. The overall response rate was 57.1 %, and the disease control rate was 100 %. Regarding hematological toxicities of grade 3 or more, leukopenia, neutropenia and thrombocytopenia occurred in 42.9, 28.6 and 14.3 %, respectively; regarding non-hematological toxicities, grade 3 rectovaginal fistula occurred in 14.3 %, as well as grade 2 fatigue in 14.3 % of the patients. The median PFS and OS were 5 months (range 3-9 months) and 7 months (range 4-43 months), respectively.

CONCLUSIONS:

These results suggest that SOX therapy is useful for the treatment of recurrent adenocarcinoma of the uterine cervix, having a promising antitumor effect and minimal adverse effects. It was also suggested that SOX therapy may contribute to improving the prognosis for patients with adenocarcinoma of the uterine cervix.

• Authors: Eriko Takatori, Tadahiro Shoji, Yasuko Suga, Hanae Niinuma, Yuki Miura, Yoshitaka Kaido, Anna Takada, Masahiro Kagabu, Satoshi Takeuchi, Toru Sugiyama
• Journal: International journal of clinical oncology (Int J Clin Oncol) Vol. 19 Issue 2 Pg. 336-40 (Apr 2014) ISSN: 1437-7772 [Electronic] Japan
• PMID: 23494222 (Publication Type: Journal Article)

Chemical References

• Drug Combinations
• Organoplatinum Compounds
• Oxaliplatin
• S 1 (combination)
• Tegafur
• Oxonic Acid

Topics

• Adenocarcinoma (drug therapy, mortality, psychology)
• Administration, Oral
• Adult
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Drug Combinations
• Female
• Humans
• Middle Aged
• Neoplasm Recurrence, Local (drug therapy, mortality, psychology)
• Organoplatinum Compounds (administration & dosage, adverse effects)
• Oxaliplatin
• Oxonic Acid (administration & dosage, adverse effects)
• Pilot Projects
• Quality of Life
• Tegafur (administration & dosage, adverse effects)
• Uterine Cervical Neoplasms (drug therapy, mortality, psychology)