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Assessment of oxidative stress in tumors and histologically normal mucosa from patients with head and neck squamous cell carcinoma: a preliminary study.

Abstract
Over 90% of head and neck cancers are squamous cell carcinomas (HNSCC) and the overall 5-year survival rate is up to 50%. The redox status of these cancers is an important factor in carcinogenesis and plays a role in radioresistance and therefore locoregional recurrences. However, knowledge of the redox status is rather limited. Glutathione is the major reactive oxygen species scavenger in normal cells. We compared the levels of tissue redox potential in HNSCC tumor tissue and compared them with those of the adjacent, histologically cancer-free, mucosa. A total of 36 patients with HNSCC were included in the study. The redox status of tumor and normal adjacent tissue was measured by the oxidized/reduced glutathione (GSSG/GSH) ratio in capillary electrophoresis. The GSSG/GSH ratio in the tumor tissue was lower compared with adjacent normal tissue in 38% of the patients. Pretherapy HNSCC tumor tissue has variable GSH levels compared with adjacent cancer-free mucosa. This difference was not related to clinical and pathological parameters. Further studies are required to determine whether the GSSG/GSH ratio plays a role in carcinogenesis and could predict radioresistance.
AuthorsDidier Dequanter, Maureen Van de Velde, Vincent Nuyens, Nathalie Nagy, Paul Van Antwerpen, Luc Vanhamme, Karim Zouaoui Boudjeltia, Michel Vanhaeverbeek, Dany Brohée, Philippe Lothaire
JournalEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) (Eur J Cancer Prev) Vol. 22 Issue 6 Pg. 558-60 (Nov 2013) ISSN: 1473-5709 [Electronic] England
PMID23492956 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Glutathione
  • Glutathione Disulfide
Topics
  • Aged
  • Carcinoma, Squamous Cell (metabolism, pathology)
  • Case-Control Studies
  • Cell Differentiation
  • Electrophoresis, Capillary
  • Female
  • Follow-Up Studies
  • Glutathione (metabolism)
  • Glutathione Disulfide (metabolism)
  • Head and Neck Neoplasms (metabolism, pathology)
  • Humans
  • Male
  • Middle Aged
  • Mouth Mucosa (metabolism)
  • Neoplasm Grading
  • Oxidation-Reduction
  • Oxidative Stress
  • Prognosis
  • Prospective Studies

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