[Pregnancy-Associated Breast Cancer: An analytical observational study].

Abstract

BACKGROUND AND OBJECTIVE:

Pregnancy-associated breast cancer is defined as breast cancer diagnosed during pregnancy and up to one year postpartum.

PATIENTS AND METHOD:

A retrospective, analytical, observational study comparing 56 cases of breast cancer and pregnancy (PABC) diagnosed 1976-2008 with 73 patients with breast cancer not associated with pregnancy (non-PABC) was performed. Demographic data, prognostic factors, treatment and survival were reviewed and compared.

RESULTS:

The prevalence of PABC in our center is 8.3/10,000. The highest frequency (62%) appeared during the postpartum period. The stages are higher in PABC, being 31.3% advanced (EIII and EIV) in PABC versus 13.3% in non-PABC (P < .05). Regarding prognostic factors, 27.3% in PABC had a tumoral grade 3 versus 15.8% of non-PABC. Among women with PABC, 33.3% had negative estrogen receptors, 48.7% negative progesterone receptors and 34.5% positive Her2Neu compared with 22.2, 24.1 and 31%, respectively of non-PABC patients. Finally, positive lymph nodes were found in 52.8% of PABC, versus 33.8% non-PABC (P < .05). Overall and disease-free survival rate at 5 years for PABC was 63.7 and 74.2%, respectively.

CONCLUSIONS:

The poorer survival observed is possibly due to the presence of adverse prognostic features such as lymph node metastases, negative hormone receptors, tumoral grade iii, as well as a delay in diagnosis with a higher rate of advanced stages.

• Authors: Sonia Baulies, Maite Cusidó, Francisco Tresserra, Ignacio Rodríguez, Belén Ubeda, Carmen Ara, Rafael Fábregas
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 142 Issue 5 Pg. 200-4 (Mar 04 2014) ISSN: 1578-8989 [Electronic] Spain
• Vernacular Title: Cáncer de mama asociado al embarazo: estudio analítico observacional.
• PMID: 23490493 (Publication Type: English Abstract, Journal Article)
• Copyright: Copyright © 2012 Elsevier España, S.L. All rights reserved.

Chemical References

• Biomarkers, Tumor

Topics

• Adult
• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (diagnosis, metabolism, mortality, therapy)
• Carcinoma (diagnosis, metabolism, mortality, therapy)
• Case-Control Studies
• Combined Modality Therapy
• Female
• Follow-Up Studies
• Humans
• Lymphatic Metastasis
• Pregnancy
• Pregnancy Complications, Neoplastic (diagnosis, metabolism, mortality, therapy)
• Prognosis
• Puerperal Disorders (diagnosis, metabolism, mortality, therapy)
• Retrospective Studies
• Survival Analysis