Abstract | BACKGROUND AND OBJECTIVE: Epidemiological studies have shown that the prevalence of adult asthma and severe asthma is higher in women. It has also been reported that female mice are more susceptible than males to the development of allergic airway inflammation and airway hyperresponsiveness (AHR). The influence of gender difference in the pathogenesis of severe asthma, especially airway remodelling in an animal model, has been studied rarely. We investigated gender difference in the development of airway remodelling using a long-term antigen-challenged mouse asthma model. METHODS: RESULTS: In OVA-sensitized and OVA-challenged (OVA/OVA) female mice, eosinophils, lymphocytes, T-helper type 2 cytokines and growth factors in bronchoalveolar lavage fluid were increased compared with OVA/OVA male mice. Histological features of airway remodelling were also increased in OVA/OVA female mice. Serum total and OVA-specific immunoglobulin E ( IgE) and serum IgA were significantly elevated in OVA/OVA female mice. CONCLUSIONS:
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Authors | Masahide Takeda, Masako Tanabe, Wataru Ito, Shigeharu Ueki, Yasunori Konnno, Mami Chihara, Masamichi Itoga, Yoshiki Kobayashi, Yuki Moritoki, Hiroyuki Kayaba, Junichi Chihara |
Journal | Respirology (Carlton, Vic.)
(Respirology)
Vol. 18
Issue 5
Pg. 797-806
(Jul 2013)
ISSN: 1440-1843 [Electronic] Australia |
PMID | 23490273
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology. |
Chemical References |
- Chemokines
- Cytokines
- Gonadal Steroid Hormones
- Immunoglobulin A
- Immunoglobulin G
- Intercellular Signaling Peptides and Proteins
- Immunoglobulin E
- Ovalbumin
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Topics |
- Airway Remodeling
(physiology)
- Animals
- Asthma
(chemically induced, metabolism, physiopathology)
- Chemokines
(metabolism)
- Cytokines
(metabolism)
- Disease Models, Animal
- Female
- Gonadal Steroid Hormones
(physiology)
- Immunoglobulin A
(metabolism)
- Immunoglobulin E
(metabolism)
- Immunoglobulin G
(metabolism)
- Injections, Intraperitoneal
- Intercellular Signaling Peptides and Proteins
(metabolism)
- Male
- Mice
- Mice, Inbred BALB C
- Ovalbumin
(administration & dosage, adverse effects)
- Sex Factors
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