Abstract | BACKGROUND: METHODS: In our open-label, parallel-group, prospective, randomised, controlled trial at two hospitals in Taiwan, patients were aged 15-40 years and had a first episode of primary spontaneous pneumothorax with a rim of air greater than 2 cm on chest radiographs, complete lung expansion without air leakage after pigtail catheter drainage, adequate haematological function, and normal renal and hepatic function. After simple aspiration and drainage via a pigtail catheter, patients were randomly assigned (1:1) to receive 300 mg of minocycline pleurodesis or no further treatment (control group). Randomisation was by computer-generated random numbers in sealed envelopes. Our primary endpoint was rate of pneumothorax recurrence at 1 year. This trial is registered with ClinicalTrials.gov (NCT00418392). FINDINGS: Between Dec 31, 2006, and June 30, 2012, 214 patients were randomly assigned-106 to the minocycline group and 108 to the control group (intention-to-treat population). Treatment was unsuccessful within 7 days of randomisation in 14 patients in the minocycline group and 20 patients in the control group. At 1 year, pneumothoraces had recurred in 31 of 106 (29·2%) patients in the minocycline group compared with 53 of 108 (49·1%) in the control group (p=0·003). We noted no procedure-related complications in either group. INTERPRETATION: FUNDING: Department of Health and National Science Council, Taiwan.
|
Authors | Jin-Shing Chen, Wing-Kai Chan, Kung-Tsao Tsai, Hsao-Hsun Hsu, Chien-Yu Lin, Ang Yuan, Wen-Jone Chen, Hong-Shiee Lai, Pan-Chyr Yang |
Journal | Lancet (London, England)
(Lancet)
Vol. 381
Issue 9874
Pg. 1277-82
(Apr 13 2013)
ISSN: 1474-547X [Electronic] England |
PMID | 23489754
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
Chemical References |
- Anti-Bacterial Agents
- Minocycline
|
Topics |
- Adolescent
- Adult
- Anti-Bacterial Agents
(administration & dosage)
- Drainage
(methods)
- Female
- Follow-Up Studies
- Humans
- Male
- Minocycline
(administration & dosage)
- Pleurodesis
(methods)
- Pneumothorax
(prevention & control, therapy)
- Prospective Studies
- Secondary Prevention
- Treatment Outcome
- Young Adult
|