Abstract | BACKGROUND: OBJECTIVE: METHODS: A literature search, including experimental and clinical studies, with no time limit was performed. RESULTS/CONCLUSION:
Stiripentol represents a group of drugs indirectly enhancing GABA-ergic neurotransmission and it exerts a protective activity in some experimental seizure models, including maximal electroshock (MES)-, pentylenetetrazol-, bicuculline-, strychnine-, and cocaine-induced convulsions. The drug potently inhibits metabolism of other antiepileptic drugs, significantly elevating their plasma and brain concentrations. This requires dosage adjustments of the concomitant antiepileptic drugs used in combination. In the form of an add-on therapy, stiripentol has proved to be effective in partial and atypical absence epilepsies. Considering its particular efficacy against severe myoclonic seizures in infancy (Dravet's syndrome), stiripentol has been awarded an orphan drug status for an adjunctive therapy of this difficult-to-treat condition.
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Authors | Stanislaw J Czuczwar, Michal K Trojnar, Aleksandra Gergont, Slawomir Kroczka, Marek Kacinski |
Journal | Expert opinion on drug discovery
(Expert Opin Drug Discov)
Vol. 3
Issue 4
Pg. 453-60
(Apr 2008)
ISSN: 1746-0441 [Print] England |
PMID | 23489100
(Publication Type: Journal Article)
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