[Effect of the leucine enkephalin analog dalargin on the components of the sympathetico-adrenal system in experimental myocardial infarction].

Abstract

A histofluorescence study was made of catecholamine saturation of the adrenergic nervous plexuses of the intact zone of rabbit left ventricles and adrenal medullas on days 3 and 7 of experimental myocardial infarction induced by ligation of the anterior branch of the left coronary artery when dalargrin, a leucine-enkephalin analogue, was administered. Dalargin was shown to decrease catecholamine saturation of myocardial nervous plexuses and to reduce detection rates of mediator accumulation in the sympathetic axons of nervous fascicles. In addition, the agent caused a decrease in the hormone content in chromaffinocytes on day 3 of the experiment and contributed to recovery of their functional homogeneity.

• Authors: N I Afonskaia, A Iu Anikin, R A Kargina-Terent'eva
• Journal: Kardiologiia (Kardiologiia) Vol. 30 Issue 2 Pg. 78-81 (Feb 1990) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Vliianie analoga leĭtsin-énkefalina-dalargina-na sostoianie komponentov simpatiko-adrenalovoĭ sistemy pri eksperimental'- nom infarkte miokarda.
• PMID: 2348626 (Publication Type: Journal Article)

Chemical References

• Catecholamines
• Enkephalin, Leucine
• Enkephalin, Leucine-2-Alanine
• enkephalin-Leu, Ala(2)-Arg(6)-

Topics

• Adrenal Medulla (drug effects, metabolism)
• Adrenergic Fibers (drug effects, metabolism)
• Animals
• Catecholamines (antagonists & inhibitors, metabolism)
• Depression, Chemical
• Enkephalin, Leucine (analogs & derivatives, therapeutic use)
• Enkephalin, Leucine-2-Alanine (analogs & derivatives)
• Heart (innervation)
• Male
• Myocardial Infarction (drug therapy, metabolism)
• Rabbits