[Effect of N-propylajmaline bromide on the normal and abnormal automatism of Purkinje fibers in the dog].

Abstract

The effects of prajmalium bromide on normal and abnormal automaticity were studied in Purkinje fibers from dog hearts at late stages of experimental myocardial infarction. Prajmalium bromide (1.2 micromol/l) moderately reduced the frequency of normal and abnormal automaticity by 16 and 20% respectively. Prajmalium bromide induced early after-depolarizations, increased the frequency of spontaneous firing and decreased the maximum diastolic potential in the fibers that initially developed the automaticity of an intermediate type between normal and abnormal. It is suggested that antiarrhythmic effects of prajmalium bromide in the late stage of experimental myocardial infarction are not related to the influence of the drug on the abnormal automaticity in Purkinje fibers.

• Authors: E A Sosunov, Ia V Kostin, V P Balashov
• Journal: Kardiologiia (Kardiologiia) Vol. 30 Issue 2 Pg. 70-4 (Feb 1990) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie N-propilaĭmalinbromida na normal'nuiu i anomal'nuiu avtomatiiu volokon Purkin'e sobaki.
• PMID: 2348624 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Culture Media
• Ajmaline
• Prajmaline

Topics

• Action Potentials (drug effects, physiology)
• Ajmaline (analogs & derivatives)
• Animals
• Culture Media
• Diastole (drug effects, physiology)
• Dogs
• Dose-Response Relationship, Drug
• Heart Conduction System (drug effects)
• In Vitro Techniques
• Myocardial Contraction (drug effects)
• Myocardial Infarction (physiopathology)
• Prajmaline (administration & dosage, pharmacology)
• Purkinje Fibers (drug effects, physiopathology)
• Time Factors