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Expression of Rac1, HIF-1α, and VEGF in gastric carcinoma: correlation with angiogenesis and prognosis.

AbstractBACKGROUND:
The aim of this study was to investigate the relationship between the expression of hypoxia-inducible factor-1α (HIF-1α), Ras-related C3 botulinum toxin substrate 1 (Rac1), and vascular endothelial growth factor (VEGF), as well as their correlation with angiogenesis and prognosis in gastric carcinoma.
MATERIAL AND METHODS:
The expression of Rac1, HIF-1α, VEGF, and CD34 (described in terms of microvessel density, MVD) was determined by immunohistochemical staining of tissues from 60 radically resected gastric cancer specimens.
RESULTS:
The proportion of specimens expressing Rac1, HIF-1α, and VEGF was 37/60 (61.7%), 35/60 (58.3%), and 40/60 (66.7%), respectively. The levels of Rac1, HIF-1α, and VEGF expression were significantly correlated with Lauren's classification, lymph node metastasis, and pathologic staging (p < 0.05). There were positive correlations between MVD and the expression of Rac1, HIF-1α, and VEGF. The mean survival time and 5-year survival rate in cases with positive Rac1, HIF-1α, and VEGF expression and MVD ≥ 26.3 were significantly shorter than those with negative Rac1, HIF-1α, and VEGF expression and MVD < 26.3.
CONCLUSION:
Rac1, HIF-1α, and VEGF play an important role in tumor invasion and metastasis, especially in tumor angiogenesis. Thus, testing the expression of Rac1, HIF-1α, and VEGF may be a useful index for treatment and prognosis.
AuthorsHongjie Zhan, Han Liang, Xiangyu Liu, Jingyu Deng, Baogui Wang, Xishan Hao
JournalOnkologie (Onkologie) Vol. 36 Issue 3 Pg. 102-7 ( 2013) ISSN: 1423-0240 [Electronic] Switzerland
PMID23485997 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 S. Karger AG, Basel.
Chemical References
  • Biomarkers, Tumor
  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • RAC1 protein, human
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • rac1 GTP-Binding Protein
Topics
  • Adult
  • Aged
  • Biomarkers, Tumor (analysis)
  • China (epidemiology)
  • Comorbidity
  • Female
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit (analysis)
  • Male
  • Middle Aged
  • Neovascularization, Pathologic (diagnosis, metabolism, mortality)
  • Prevalence
  • Prognosis
  • Reproducibility of Results
  • Risk Assessment
  • Sensitivity and Specificity
  • Statistics as Topic
  • Stomach Neoplasms (diagnosis, metabolism, mortality)
  • Survival Analysis
  • Survival Rate
  • Vascular Endothelial Growth Factor A (analysis)
  • rac1 GTP-Binding Protein (analysis)

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