Expression of Rac1, HIF-1α, and VEGF in gastric carcinoma: correlation with angiogenesis and prognosis.
Abstract | BACKGROUND: MATERIAL AND METHODS: The expression of Rac1, HIF-1α, VEGF, and CD34 (described in terms of microvessel density, MVD) was determined by immunohistochemical staining of tissues from 60 radically resected gastric cancer specimens. RESULTS: The proportion of specimens expressing Rac1, HIF-1α, and VEGF was 37/60 (61.7%), 35/60 (58.3%), and 40/60 (66.7%), respectively. The levels of Rac1, HIF-1α, and VEGF expression were significantly correlated with Lauren's classification, lymph node metastasis, and pathologic staging (p < 0.05). There were positive correlations between MVD and the expression of Rac1, HIF-1α, and VEGF. The mean survival time and 5-year survival rate in cases with positive Rac1, HIF-1α, and VEGF expression and MVD ≥ 26.3 were significantly shorter than those with negative Rac1, HIF-1α, and VEGF expression and MVD < 26.3. CONCLUSION: Rac1, HIF-1α, and VEGF play an important role in tumor invasion and metastasis, especially in tumor angiogenesis. Thus, testing the expression of Rac1, HIF-1α, and VEGF may be a useful index for treatment and prognosis.
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Authors | Hongjie Zhan, Han Liang, Xiangyu Liu, Jingyu Deng, Baogui Wang, Xishan Hao |
Journal | Onkologie
(Onkologie)
Vol. 36
Issue 3
Pg. 102-7
( 2013)
ISSN: 1423-0240 [Electronic] Switzerland |
PMID | 23485997
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 S. Karger AG, Basel. |
Chemical References |
- Biomarkers, Tumor
- HIF1A protein, human
- Hypoxia-Inducible Factor 1, alpha Subunit
- RAC1 protein, human
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- rac1 GTP-Binding Protein
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(analysis)
- China
(epidemiology)
- Comorbidity
- Female
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit
(analysis)
- Male
- Middle Aged
- Neovascularization, Pathologic
(diagnosis, metabolism, mortality)
- Prevalence
- Prognosis
- Reproducibility of Results
- Risk Assessment
- Sensitivity and Specificity
- Statistics as Topic
- Stomach Neoplasms
(diagnosis, metabolism, mortality)
- Survival Analysis
- Survival Rate
- Vascular Endothelial Growth Factor A
(analysis)
- rac1 GTP-Binding Protein
(analysis)
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