Abstract | PURPOSE/OBJECTIVE: MATERIALS AND METHODS: In this institutional review board-approved study, our database of 1450 patients with endometrial cancer was reviewed. Seventy-nine surgically staged patients with 2009 International Federation of Gynecology and Obstetrics (FIGO) stages I and II serous and clear cell carcinoma were treated from 1991 to 2010. These patients were then divided into 2 groups; one group received adjuvant RT, and the other group included patients who did not receive adjuvant RT. RESULTS: The median age of the study cohort is 65 years, and the median follow-up is 47 months. Thirty-nine patients (49%) received adjuvant RT, and 40 patients did not. The 5-year RFS was significantly improved in patients who received RT (84% vs 58%; P = 0.002). Similarly, 5-year DSS was significantly improved in patients who received RT (87% vs 58%; P = 0.023) with a trend toward improved 5-year overall survival (74% vs 58%; P = 0.088). On multivariate analysis, lack of angiolymphatic invasion (P < 0.001 and P < 0.001), adjuvant RT (P < 0.001 and P = 0.004), and lack of lower uterine segment involvement (P = 0.007 and P = 0.009) were independent predictors of improved RFS and DSS, respectively. CONCLUSIONS: In the current study of surgically staged patients with type II endometrial carcinoma International Federation of Gynecology and Obstetrics stages I and II, adjuvant radiation therapy with or without chemotherapy resulted in a significant improvement in recurrence-free and disease-specific survival.
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Authors | Raphael Yechieli, Nabila Rasool, Jared R Robbins, Chad M Cogan, Mohamed A Elshaikh |
Journal | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
(Int J Gynecol Cancer)
Vol. 23
Issue 4
Pg. 763-8
(May 2013)
ISSN: 1525-1438 [Electronic] England |
PMID | 23485931
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma
(mortality, radiotherapy)
- Endometrial Neoplasms
(mortality, radiotherapy)
- Female
- Humans
- Middle Aged
- Neoplasm Recurrence, Local
(prevention & control)
- Radiotherapy, Adjuvant
- Retrospective Studies
- United States
(epidemiology)
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