Abstract | BACKGROUND:
Breast cancer is the most commonly diagnosed cancer in women. Obesity is an important risk factor for developing breast cancer and is one of few risk factors that women can modify to prevent cancer. (-)- Gossypol-enriched cottonseed oil [(-)-GPCSO] contains 65% (-)- gossypol and 35% (+)- gossypol. Previous studies have demonstrated that both (-)- gossypol and (-)-GPCSO have potent anticancer activity against multiple types of cancer, including breast cancer. In addition, (-)-GPCSO reduced body weight gain and food intake in young female rats. However, the role of (-)-GPCSO on adipogenesis in human breast pre-adipocytes remains unclear. MATERIALS AND METHODS: RESULTS: (-)-GPCSO inhibited proliferation of pre-adipocytes and down-regulated the expression of cyclin-D1 and BCL-2. (-)-GPCSO also significantly decreased adipogenesis, as determined by inhibition of GPDH activity, triglyceride content (TG), and down-regulation of the expression of PPARγ, C/EBPα and leptin. CONCLUSION: These findings suggest that (-)-GPCSO has the potential as a food supplement to inhibit adipogenesis, and therefore, reduce obesity.
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Authors | Saiyi Zhong, John Leong, Weiping Ye, Pingping Xu, Shu-Hong Lin, Jie-Yu Liu, Young C Lin |
Journal | Anticancer research
(Anticancer Res)
Vol. 33
Issue 3
Pg. 949-55
(Mar 2013)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 23482766
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CCAAT-Enhancer-Binding Protein-alpha
- CCND1 protein, human
- Cottonseed Oil
- Leptin
- PPAR gamma
- Cyclin D1
- Gossypol
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Topics |
- Adipocytes
(cytology, drug effects)
- Adipogenesis
(drug effects)
- Breast
(cytology, drug effects, metabolism)
- CCAAT-Enhancer-Binding Protein-alpha
(genetics)
- Cell Proliferation
(drug effects)
- Cottonseed Oil
(pharmacology)
- Cyclin D1
(genetics)
- Female
- Genes, bcl-2
- Gossypol
(pharmacology)
- Humans
- Leptin
(genetics)
- PPAR gamma
(genetics)
- Stem Cells
(drug effects)
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