Toxicity and therapy of cisplatin-loaded EGF modified mPEG-PLGA-PLL nanoparticles for SKOV3 cancer in mice.

Abstract	Construction on the nanoparticles with lower toxicity and specific tumor targeting properties is challenging and requires careful design of composition, size, physicochemical properties tailored for the nanoparticles. Here the epidermal growth factor (EGF) modified methoxy polyethylene glycol-polylactic-co-glycolic acid-polylysine (mPEG-PLGA-PLL) encapsulated cisplatin (CDDP) nanoparticles (CDDP-NPs-EGF) was prepared to for solving the toxicity of CDDP and improving therapeutic efficiency. The remarkable features of CDDP-NPs-EGF are increasing cytotoxicity that attribute to effective cell cycle arrest and high cell apoptosis in vitro. In vivo, the CDDP-NPs-EGF change drug distribution, decrease the nephrotoxicity of CDDP and improve significantly therapeutic efficiency without inducing obvious system toxicity, verifying its key role of the CDDP-NPs-EGF in lowering drug toxicity and enhancing the antitumor efficiency for SKOV3 cancer in mice.
Authors	Yunfei Wang, Peifeng Liu, Lihua Qiu, Ying Sun, Mingjie Zhu, Liying Gu, Wen Di, Yourong Duan
Journal	Biomaterials (Biomaterials) Vol. 34 Issue 16 Pg. 4068-4077 (May 2013) ISSN: 1878-5905 [Electronic] Netherlands
PMID	23480957 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.
Chemical References	Antineoplastic Agents Polyesters methoxypolyethyleneglycol-poly(lactic-co-glycolic acid) Polylysine Polyethylene Glycols Epidermal Growth Factor Cisplatin
Topics	Animals Antineoplastic Agents (pharmacology, therapeutic use) Apoptosis (drug effects) Cell Cycle (drug effects) Cell Death (drug effects) Cell Line, Tumor Cell Survival (drug effects) Cisplatin (pharmacology, therapeutic use) Epidermal Growth Factor (pharmacology) Female Flow Cytometry Humans Mice Microscopy, Confocal Nanoparticles (toxicity, ultrastructure) Ovarian Neoplasms (drug therapy, pathology) Polyesters (chemistry) Polyethylene Glycols (chemistry) Polylysine (chemistry) Tissue Distribution (drug effects) Treatment Outcome Xenograft Model Antitumor Assays

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