Abstract | OBJECTIVES: Grape seed proanthocyanidin extract (GSPE) is a potent antioxidant and a free radical scavenger. This study was designed to determine whether GSPE could protect against dysfunction and oxidative stress induced by torsion-detorsion injury in rat testis. METHODS: A total of 45 male Wistar albino rats were divided into five groups: control group, sham group, torsion-detorsion (T/D) group, T/D + GSPE group, GSPE group. GSPE was administrated 100 mg/kg/day with oral gavage over seven days before torsion. Testicular torsion was performed for 2 h, and afterward, detorsion was performed for 2 h. The rats were decapitated under ketamine anesthesia, and their testes tissues were removed. Tissue malondialdehyde, advanced oxidation protein products levels, eNOS expression, apoptosis and histopathological damage scores were then compared. RESULTS: CONCLUSIONS:
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Authors | Firuze Bayatli, Derya Akkuş, Eser Kilic, Recep Saraymen, Mehmet Fatih Sönmez |
Journal | World journal of urology
(World J Urol)
Vol. 31
Issue 3
Pg. 615-22
(Jun 2013)
ISSN: 1433-8726 [Electronic] Germany |
PMID | 23475212
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Advanced Oxidation Protein Products
- Antioxidants
- Grape Seed Extract
- Malondialdehyde
- Nitric Oxide Synthase Type III
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Topics |
- Advanced Oxidation Protein Products
(metabolism)
- Animals
- Antioxidants
(pharmacology, therapeutic use)
- Apoptosis
(drug effects)
- Disease Models, Animal
- Grape Seed Extract
(pharmacology, therapeutic use)
- Male
- Malondialdehyde
(metabolism)
- Nitric Oxide Synthase Type III
(metabolism)
- Rats
- Rats, Wistar
- Reperfusion Injury
(prevention & control)
- Spermatic Cord Torsion
(metabolism, pathology)
- Testis
(drug effects, metabolism, pathology)
- Treatment Outcome
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