Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: Patients were predominantly male (65.2%), with an average (SD) age of 66.6 (9.9) years, with urologic (44.9%), rectal (24.6%), or gynecological cancer (23.1%). More patients developed enteritis with glutamine than with the placebo (55.9% vs 22.0%; P = .002), with an HR OF 1.59 (95% confidence interval, 0.624.05). There were no differences in final calprotectin levels ( glutamine, 57.9 [85.8] mg/kg vs placebo, 54.0 [57.7] mg/kg; p = .182) or the number of patients with values 50 mg/kg ( glutamine, 58.1% vs placebo, 54.6%; p = .777). Final citrulline levels were similar between groups ( glutamine, 26.31 [10.29] mmol/l vs placebo, 27.69 [12.31] mmol/l; p = .639), without differences in the number of patients with 20 mmol/ l (glutamine, 24.1% vs placebo, 25.0%; P = .938). Citrulline concentration was reduced during rt with placebo but remained unchanged with glutamine. CONCLUSION:
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Authors | Alfonso Vidal-Casariego, Alicia Calleja-Fernández, Juan José Ortiz de Urbina-González, Isidoro Cano-Rodríguez, Fernando Cordido, María D Ballesteros-Pomar |
Journal | JPEN. Journal of parenteral and enteral nutrition
(JPEN J Parenter Enteral Nutr)
Vol. 38
Issue 2
Pg. 205-13
(Feb 2014)
ISSN: 1941-2444 [Electronic] United States |
PMID | 23471208
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Leukocyte L1 Antigen Complex
- Glutamine
- Citrulline
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Topics |
- Acute Disease
- Aged
- Citrulline
(blood)
- Double-Blind Method
- Enteritis
(pathology, prevention & control)
- Female
- Glutamine
(pharmacology)
- Humans
- Inflammation
(drug therapy)
- Intestinal Mucosa
(pathology, radiation effects)
- Intestines
(pathology, radiation effects)
- Leukocyte L1 Antigen Complex
(blood)
- Male
- Middle Aged
- Nutrition Assessment
- Nutritional Status
- Proportional Hazards Models
- Radiotherapy
(adverse effects)
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