Abstract |
Conformational analysis of the marine cembranoid sarcophytol A (1a), a potent anti-tumor promoter, was carried out using a newly introduced molecular mechanic and molecular dynamic program Discover. Four minimum-energy conformations were derived, in accordance with a previous results of the epoxidation of 1a, which afforded 7R,8R/7S,8S- and 11R,12R/11S,12S-epoxide pairs. The most stable conformation was the one having C-19 and C-20 directed opposite to C-18, with respect to the average plane of the fourteen-membered ring. X-Ray crystallography of sarcophytol A alpha-methoxy-alpha-trifluoromethylphenylacetate (1c) was carried out simultaneously. This confirmed the 14S absolute configuration of 1a but the conformation of crystalline 1c did not correspond to any of the four minimum-energy conformers of 1a.
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Authors | M Kobayashi, K Kobayashi, M Nomura, H Munakata |
Journal | Chemical & pharmaceutical bulletin
(Chem Pharm Bull (Tokyo))
Vol. 38
Issue 3
Pg. 815-7
(Mar 1990)
ISSN: 0009-2363 [Print] Japan |
PMID | 2347029
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Crystallization
- Diterpenes
(analysis)
- Models, Chemical
- Molecular Conformation
- X-Ray Diffraction
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