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Improved cardiac performance with human calcitonin gene related peptide in patients with congestive heart failure.

AbstractSTUDY OBJECTIVE:
The aim of the study was to assess the cardiovascular effects of human calcitonin gene related peptide (CGRP) in patients with congestive heart failure.
DESIGN:
The effects of CGRP II (or beta), 12.5 micrograms.h-1, given by intravenous infusion for 24 h to digitalised patients with congestive heart failure, were assessed by measurement of cardiac functional indices.
PATIENTS:
Five patients (four female) were studied. Age was 73-82 years. Three were in New York Heart Association phase III and two in phase IV.
MEASUREMENTS AND MAIN RESULTS:
The pre-ejection period to left ventricular ejection time ratio and the QT distance adjusted for heart rate were lowered by 21% and 4% respectively. The left ventricular shortening index was raised by 43%. The arterial pressure and heart rate did not change consistently.
CONCLUSION:
Calcitonin gene related peptide improves myocardial contractility in patients with congestive heart failure. This is the first time this has been shown.
AuthorsC Gennari, R Nami, D Agnusdei, J A Fischer
JournalCardiovascular research (Cardiovasc Res) Vol. 24 Issue 3 Pg. 239-41 (Mar 1990) ISSN: 0008-6363 [Print] England
PMID2346957 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Calcitonin Gene-Related Peptide
Topics
  • Aged
  • Aged, 80 and over
  • Calcitonin Gene-Related Peptide (therapeutic use)
  • Dose-Response Relationship, Drug
  • Female
  • Heart (physiopathology)
  • Heart Failure (drug therapy, physiopathology)
  • Humans
  • Male
  • Myocardial Contraction (drug effects)
  • Stimulation, Chemical

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