Abstract | OBJECTIVES: METHODS: The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total). RESULTS: The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance. CONCLUSIONS: Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.
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Authors | Zhenhua Hu, Jian Gao, Danye Zhang, Qing Liu, Limei Yan, Lili Gao, Juanjuan Liu, Dawo Liu, Shulan Zhang, Bei Lin |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 2
Pg. e57250
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23468946
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hyaluronan Receptors
- Lewis Blood Group Antigens
- Lewis Y antigen
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Topics |
- Carcinoma, Ovarian Epithelial
- Drug Resistance, Neoplasm
(immunology)
- Female
- Humans
- Hyaluronan Receptors
(immunology)
- Immunohistochemistry
- Lewis Blood Group Antigens
(immunology)
- Middle Aged
- Multivariate Analysis
- Neoplasms, Glandular and Epithelial
(drug therapy, immunology)
- Ovarian Neoplasms
(drug therapy, immunology)
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