Cyclophosphamide-induced generalised reticulated skin pigmentation: a rare presentation.

Abstract

CASE:

We describe a 55-year-old woman suffering from Sezary syndrome, had undergone chemotherapy consisting of cycles of cyclophosphamide and prednisone. 10 months later, she noticed a progressively increasing reticulated generalised pigmentation in the face, trunk and the extremities. Cylophosphamide was withdrawn. The hyperpigmentation began to clear slowly and gradually after 7 months. One year after cyclophosphamide withdrawal and facing the relapse of the disease, and its transformation to a large T cell lymphoma a mini CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) protocol was held, leading to a remarkable aggravation of the pigmentation.

CONCLUSION:

This adverse drug reaction to cyclophosphamide is peculiar by its localization and distribution and should be known in order not to confuse with other dermatosis.

• Authors: Monia Youssef, Sana Mokni, Hichem Belhadjali, Karim Aouem, Adnène Moussa, Adnène Laatiri, Jameleddine Zili
• Journal: International journal of clinical pharmacy (Int J Clin Pharm) Vol. 35 Issue 3 Pg. 309-12 (Jun 2013) ISSN: 2210-7711 [Electronic] Netherlands
• PMID: 23468078 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Cyclophosphamide (administration & dosage, adverse effects, therapeutic use)
• Doxorubicin (adverse effects, therapeutic use)
• Female
• Humans
• Hyperpigmentation (chemically induced)
• Middle Aged
• Prednisone (adverse effects, therapeutic use)
• Sezary Syndrome (drug therapy)
• Skin Neoplasms (drug therapy)
• Skin Pigmentation (drug effects)
• Vincristine (adverse effects, therapeutic use)