Abstract | BACKGROUND: METHODS: A total of 449 PMP patients with documented preoperative CEA levels referred to our center between 2005 and 2011 underwent CRS and HIPEC. The association between CEA levels and characteristics of patients with PMP was assessed with χ (2) test, linear correlation, and logistic regression analyses. Survival analysis was performed with Cox proportional hazard model. RESULTS: Median age was 55 (range 19-84) years. There were 245 (54.5 %) females and 204 (45.5 %) males. Preoperative CEA levels were elevated in 328 (73 %, sensitivity) patients with PMP. Preoperative CEA levels were also related to peritoneal cancer index (P < 0.0001), cytoreductive surgery scores (P < 0.0001), progress free survival (P < 0.001) and overall survival (P < 0.001) in patients with PMP. CONCLUSIONS: Our results indicated that preoperative CEA levels are useful in predicting the extent of disease and surgical success as well as progress-free and overall survival in patients with PMP treated with cytoreductive surgery and HIPEC.
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Authors | Emel Canbay, Haruaki Ishibashi, Shouzou Sako, Akiyoshi Mizumoto, Masamitsu Hirano, Masumi Ichinose, Nobuyuki Takao, Yutaka Yonemura |
Journal | World journal of surgery
(World J Surg)
Vol. 37
Issue 6
Pg. 1271-6
(Jun 2013)
ISSN: 1432-2323 [Electronic] United States |
PMID | 23467926
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Carcinoembryonic Antigen
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(blood)
- Carcinoembryonic Antigen
(blood)
- Chemotherapy, Cancer, Regional Perfusion
- Female
- Humans
- Hyperthermia, Induced
- Injections, Intraperitoneal
- Male
- Middle Aged
- Peritoneal Neoplasms
(blood, drug therapy, surgery)
- Predictive Value of Tests
- Prognosis
- Pseudomyxoma Peritonei
(blood, drug therapy, surgery)
- Retrospective Studies
- Survival Rate
- Treatment Outcome
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