Abstract | BACKGROUND: METHODS: Twelve patients (body mass index [BMI] 57.6 ± 9.9 kg/m(2)) underwent BPD and 12 (BMI 43.7 ± 2.1 kg/m(2)) underwent SG. All patients had T2DM and underwent an oral glucose tolerance test (OGTT) before and 1, 3, and 12 months after surgery. RESULTS: BMI decreased more after BPD, but percent excess weight loss (%EWL) was similar in both groups (P = .8) and T2DM resolved in all patients at 12 months. Insulin sensitivity improved more after BPD than after SG (P = .003). Blood pressure, total and LDL cholesterol decreased only after BPD (P<.001). Triglycerides decreased after either operation, but HDL increased only after SG (P<.001). Fasting ghrelin did not change after BPD ( P = .2), but decreased markedly after SG (P<.001). GLP-1 and PYY responses during OGTT were dramatically enhanced after either procedure (P = .001). CONCLUSIONS: SG was comparable to BPD in T2DM resolution but inferior in improving dyslipidemia and blood pressure. SG and BPD enhanced markedly PYY and GLP-1 responses but only SG suppressed ghrelin levels.
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Authors | Marina Tsoli, Aikaterini Chronaiou, Ioannis Kehagias, Fotis Kalfarentzos, Theodore K Alexandrides |
Journal | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
(Surg Obes Relat Dis)
2013 Sep-Oct
Vol. 9
Issue 5
Pg. 667-77
ISSN: 1878-7533 [Electronic] United States |
PMID | 23466015
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2013 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Ghrelin
- Insulin
- Peptide YY
- Glucagon-Like Peptide 1
- Glucagon
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Topics |
- Adult
- Biliopancreatic Diversion
(methods)
- Diabetes Mellitus, Type 2
(blood, prevention & control)
- Dyslipidemias
(prevention & control)
- Female
- Gastrectomy
(methods)
- Ghrelin
(blood)
- Glucagon
(blood)
- Glucagon-Like Peptide 1
(blood)
- Glucose Tolerance Test
- Humans
- Hypertension
(prevention & control)
- Insulin
(blood)
- Laparoscopy
(methods)
- Luminescence
- Male
- Middle Aged
- Obesity, Morbid
(blood, surgery)
- Peptide YY
(blood)
- Prospective Studies
- Radioimmunoassay
- Treatment Outcome
- Weight Loss
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