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Three-dimensional power Doppler study of endometrial and subendometrial microvascularization in women with intrauterine device-induced menorrhagia.

AbstractOBJECTIVE:
To evaluate endometrial and subendometrial microvascularization, using three-dimensional (3D) power Doppler ultrasound, in women with intrauterine device (IUD)-induced menorrhagia; and whether those potential findings could predict the risk of bleeding before IUD insertion.
DESIGN:
Prospective clinical trial.
SETTING:
University teaching hospital.
PATIENT(S):
One hundred twenty women, who requested the insertion of a copper IUD for contraception.
INTERVENTION(S):
Endometrial thickness and volume, uterine artery pulsatility index and resistance index, and endometrial and subendometrial 3D power Doppler vascularization index, flow index, and vascularization flow index were measured twice: immediately before and 3 months after IUD insertion.
MAIN OUTCOME MEASURE(S):
Doppler indices before and after IUD insertion.
RESULT(S):
Before IUD insertion, no significant difference was detected in the clinical characteristics, endometrial thickness and volume, and Doppler indices between women who had IUD-induced menorrhagia (n = 47) and those without menorrhagia (n = 73). However, after IUD insertion, there was a significant increase in the endometrial and subendometrial vascularization index, flow index, and vascularization flow index in women with menorrhagia, whereas other parameters remained not significantly different between the two groups.
CONCLUSION(S):
Endometrial and subendometrial microvascularization increases in women with IUD-induced menorrhagia; however, this finding has no predictive value before IUD insertion.
AuthorsAkmal El-Mazny, Nermeen Abou-Salem, Hossam Elshenoufy
JournalFertility and sterility (Fertil Steril) Vol. 99 Issue 7 Pg. 1912-5 (Jun 2013) ISSN: 1556-5653 [Electronic] United States
PMID23465819 (Publication Type: Controlled Clinical Trial, Journal Article)
CopyrightCopyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Topics
  • Adult
  • Blood Flow Velocity
  • Egypt
  • Endometrium (blood supply)
  • Female
  • Hospitals, University
  • Humans
  • Imaging, Three-Dimensional
  • Intrauterine Devices, Copper (adverse effects)
  • Menorrhagia (etiology, physiopathology, ultrasonography)
  • Microvessels (physiopathology, ultrasonography)
  • Predictive Value of Tests
  • Prospective Studies
  • Pulsatile Flow
  • Regional Blood Flow
  • Risk Assessment
  • Risk Factors
  • Time Factors
  • Ultrasonography, Doppler
  • Uterine Artery (physiopathology, ultrasonography)
  • Vascular Resistance

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