Caspr2 antibodies in limbic encephalitis with cerebellar ataxia, dyskinesias and myoclonus.

Abstract

Here we report on a case of contactin-associated protein-2 (Caspr2) antibody positive but voltage gated potassium channel (VGKC) antibody negative limbic encephalitis associated with cerebellar ataxia, myoclonus and dyskinesias with favorable response to immunotherapy. This case underlines the importance of Caspr2-specific antibody testing and demonstrates that Caspr2 antibodies are associated with a broader clinical spectrum than hitherto described.

• Authors: Bettina Balint, Jens Uwe Regula, Sven Jarius, Brigitte Wildemann
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 327 Issue 1-2 Pg. 73-4 (Apr 15 2013) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 23465509 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Autoantibodies
• CNTNAP2 protein, human
• Membrane Proteins
• Nerve Tissue Proteins

Topics

• Autoantibodies (blood)
• Cerebellar Ataxia (blood, complications, diagnosis)
• Dyskinesias (blood, complications, diagnosis)
• Female
• Humans
• Limbic Encephalitis (blood, complications, diagnosis)
• Membrane Proteins (blood)
• Middle Aged
• Myoclonus (blood, complications, diagnosis)
• Nerve Tissue Proteins (blood)