Multifunctional envelope-type mesoporous silica nanoparticles for tumor-triggered targeting drug delivery.

Abstract

A novel type of cellular-uptake-shielding multifunctional envelope-type mesoporous silica nanoparticle (MEMSN) was designed for tumor-triggered targeting drug delivery to cancerous cells. β-Cyclodextrin (β-CD) was anchored on the surface of mesoporous silica nanoparticles via disulfide linking for glutathione-induced intracellular drug release. Then a peptide sequence containing Arg-Gly-Asp (RGD) motif and matrix metalloproteinase (MMP) substrate peptide Pro-Leu-Gly-Val-Arg (PLGVR) was introduced onto the surface of the nanoparticles via host-guest interaction. To protect the targeting ligand and prevent the nanoparticles from being uptaken by normal cells, the nanoparticles were further decorated with poly(aspartic acid) (PASP) to obtain MEMSN. In vitro study demonstrated that MEMSN was shielded against normal cells. After reaching the tumor cells, the targeting property could be switched on by removing the PASP protection layer via hydrolyzation of PLGVR at the MMP-rich tumor cells, which enabled the easy uptake of drug-loaded nanoparticles by tumor cells and subsequent glutathione-induced drug release intracellularly.

• Authors: Jing Zhang, Zhe-Fan Yuan, Ya Wang, Wei-Hai Chen, Guo-Feng Luo, Si-Xue Cheng, Ren-Xi Zhuo, Xian-Zheng Zhang
• Journal: Journal of the American Chemical Society (J Am Chem Soc) Vol. 135 Issue 13 Pg. 5068-73 (Apr 03 2013) ISSN: 1520-5126 [Electronic] United States
• PMID: 23464924 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Carriers
• Silicon Dioxide
• Doxorubicin

Topics

• Cell Line, Tumor
• Cell Survival (drug effects)
• Doxorubicin (pharmacology)
• Drug Carriers (chemical synthesis, chemistry)
• Humans
• Microscopy, Electron, Transmission
• Nanoparticles (chemistry)
• Neoplasms (drug therapy)
• Porosity
• Silicon Dioxide (chemistry)