Impact of postoperative infliximab maintenance therapy on preventing the surgical recurrence of Crohn's disease: a single-center paired case-control study.

Abstract

PURPOSE:

Preventing a recurrence of Crohn's disease is a problem that remains to be solved. We evaluated the impact of using infliximab as a postoperative therapy on preventing the surgical recurrence of Crohn's disease.

METHODS:

We performed a pair-matched study comparing 100 patients who had received postoperative infliximab maintenance therapy with those who had not between 1995 and 2010. The patients were matched by gender, Vienna classification and age at the time of the operation. Crohn's disease-related reoperation was evaluated as surgical recurrence.

RESULTS:

In the postoperative infliximab maintenance therapy group, infliximab was administrated within 8 weeks after the operation. The median follow-up period was 36 months in the postoperative infliximab maintenance therapy group and 51 months in the control group. Surgical recurrences were recognized in 37 patients (three in the postoperative infliximab maintenance therapy group and 34 in the control group). A univariate analysis by the Kaplan-Meier method identified a body mass index >18 at the time of the operation (HR 0.19, p = 0.01) and postoperative infliximab maintenance therapy (HR 0.22, p = 0.0022) as factors related to the reduction of surgical recurrence. The multivariate analysis revealed that postoperative infliximab maintenance therapy was the only significant factor preventing surgical recurrence.

CONCLUSION:

Postoperative infliximab maintenance therapy for Crohn's disease prevents surgical recurrence, at least within 3 years after the operation.

• Authors: Toshimitsu Araki, Keiichi Uchida, Yoshiki Okita, Hiroyuki Fujikawa, Mikihiro Inoue, Masaki Ohi, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri, Masato Kusunoki
• Journal: Surgery today (Surg Today) Vol. 44 Issue 2 Pg. 291-6 (Feb 2014) ISSN: 1436-2813 [Electronic] Japan
• PMID: 23463537 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• Infliximab
• Azathioprine

Topics

• Adult
• Antibodies, Monoclonal (administration & dosage)
• Azathioprine (administration & dosage)
• Case-Control Studies
• Cohort Studies
• Crohn Disease (epidemiology, prevention & control, surgery)
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Humans
• Incidence
• Infliximab
• Infusions, Intravenous
• Maintenance Chemotherapy
• Male
• Postoperative Care
• Proportional Hazards Models
• Reoperation
• Secondary Prevention
• Young Adult