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Serum microRNAs levels in primary focal segmental glomerulosclerosis.

AbstractBACKGROUND:
MicroRNAs (miRNAs, miRs) are involved in most physiological, developmental, and pathological processes. miR-192 and miR-205 are expressed preferentially in the renal cortex and closely relevant to the renal cell biology. In the present study, we aim to measure the serum levels of miR-192 and miR-205 and their correlation with clinicopathological data in patients with primary focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD).
METHODS:
Fifty-six patients (35 male, 21 female) with idiopathic nephrotic syndrome (FSGS 30, MCD 26) and 20 healthy controls were enrolled in the study. We quantified the serum levels of miR-192 and miR-205 in patients with FSGS and MCD by RT-qPCR.
RESULTS:
Patients with FSGS had higher serum levels of miR-192 and miR-205 than those with MCD (324.49 ± 42.74 fmol/l versus 90.19 ± 27.14 fmol/l, p < 0.01, 2.25 ± 0.69 fmol/l versus 0.60 ± 0.51 fmol/l, p < 0.01, respectively). The level of miR-192 was positively correlated with the proteinuria in patients with FSGS and MCD (r = 0.62, p < 0.001, r = 0.84, p < 0.001, respectively). Similarly, the level of miR-205 was positively correlated with the proteinuria in patients with FSGS (r = 0.54, p = 0.002). In addition, the serum level of miR-192 was significantly correlated with the degree of interstitial fibrosis in patients with FSGS (r = 0.342, p < 0.05).
CONCLUSIONS:
miR-192 and miR-205 have the potential as markers to differentiate FSGS from MCD.
AuthorsXiaoyi Cai, Zhengkun Xia, Chunni Zhang, Yang Luo, Yuanfu Gao, Zhongmin Fan, Mengyuan Liu, Ying Zhang
JournalPediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 28 Issue 9 Pg. 1797-801 (Sep 2013) ISSN: 1432-198X [Electronic] Germany
PMID23463342 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adrenal Cortex Hormones
  • MIRN192 microRNA, human
  • MIRN205 microRNA, human
  • MicroRNAs
Topics
  • Adrenal Cortex Hormones (therapeutic use)
  • Child
  • Female
  • Fibrosis
  • Glomerular Filtration Rate
  • Glomerulosclerosis, Focal Segmental (metabolism, pathology)
  • Humans
  • Kidney Function Tests
  • Male
  • MicroRNAs (blood)
  • Nephrosis, Lipoid (pathology)
  • Polymerase Chain Reaction
  • Treatment Outcome

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