Sinonasal undifferentiated carcinoma (SNUC): morphoproteomic-guided treatment paradigm with clinical efficacy.

Abstract

Sinonasal undifferentiated carcinoma (SNUC) is a rare and highly malignant tumor that occurs in the nasal cavity and/or paranasal sinuses. Prognosis is poor despite multimodality treatment. Currently, there is no optimal standard of treatment, partially due to a lack of research defining the biology of such tumors. This report discusses two SNUC cases where patients received a novel chemotherapeutic approach using cisplatin, etoposide, Adriamycin (doxorubicin), metformin, and adjuvant melatonin therapies based on morphoproteomic-guidance, followed by consolidation with chemoradiation therapy. This resulted in excellent and objective tomographic and magnetic resonance imaging and clinical responses including complete responses in the induction phase utilizing morphoproteomic-guided therapies. Later, endoscopic excision of the tumor bed failed to reveal any residual tumor. Morphoproteomics helped to define the biology of these SNUC tumors and provided targets for the agents employed, creating a new treatment paradigm for such tumors. This treatment regimen poses a new effective regimen to treat SNUC.

• Authors: Maria Ansari, Shan Guo, Samer Fakhri, Martin J Citardi, Angel Blanco, Maria Patino, Jamie Buryanek, Robert Amato, Ron Karni, Robert E Brown
• Journal: Annals of clinical and laboratory science (Ann Clin Lab Sci) Vol. 43 Issue 1 Pg. 45-53 ( 2013) ISSN: 1550-8080 [Electronic] United States
• PMID: 23462605 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Carcinoma (diagnostic imaging, metabolism, pathology, therapy)
• Endoscopy
• Female
• Follow-Up Studies
• Humans
• Induction Chemotherapy
• Magnetic Resonance Imaging
• Male
• Maxillary Sinus Neoplasms (diagnostic imaging, metabolism, pathology, therapy)
• Nasal Cavity (pathology)
• Proteomics
• Staining and Labeling
• Tomography, X-Ray Computed
• Treatment Outcome
• Young Adult