Neuroprotective effects of salvianolic acid B on an Aβ25-35 peptide-induced mouse model of Alzheimer's disease.

Abstract

Salvianolic acid B (SalB) is a polyphenolic compound found in Salvia miltiorrhiza Bunge that has several anti-oxidative and anti-inflammatory effects. In the present study, we investigated whether SalB has neuroprotective effects in an amyloid β (Aβ) peptide-induced Alzheimer's disease mouse model. Mice were injected with Aβ25-35 peptide intracerebroventricularly and were subsequently administered SalB once daily for 7 days. Subchronic SalB administration (10mg/kg) significantly ameliorated the Aβ25-35 peptide-induced memory impairment in the passive avoidance task (P<0.05). SalB treatment also reduced the number of activated microglia and astrocytes that were observed during the inflammatory reaction after the administration of the Aβ25-35 peptide. Moreover, SalB markedly reduced inducible nitric oxide synthase and cyclooxygenase-2 expression levels and thiobarbituric acid reactive substances, which were increased by the administration of the Aβ25-35 peptide. Furthermore, SalB administration significantly rescued the Aβ25-35 peptide-induced decrease of choline acetyltransferase and brain-derived neurotrophic factor protein levels. These results suggest that SalB exerts neuroprotective activity via anti-inflammatory and anti-oxidative effects and that SalB may be a potential candidate for Alzheimer's disease therapy.

• Authors: Young Woo Lee, Dong Hyun Kim, Su Jin Jeon, Se Jin Park, Jong Min Kim, Jun Man Jung, Hyung Eun Lee, Shin Gil Bae, Hee Kyong Oh, Kun Ho Son, Kun Ho Ho Son, Jong Hoon Ryu
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 704 Issue 1-3 Pg. 70-7 (Mar 15 2013) ISSN: 1879-0712 [Electronic] Netherlands
• PMID: 23461850 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Amyloid beta-Peptides
• Anti-Inflammatory Agents
• Benzofurans
• Brain-Derived Neurotrophic Factor
• Neuroprotective Agents
• Peptide Fragments
• amyloid beta-protein (25-35)
• salvianolic acid B
• Nitric Oxide Synthase Type II
• Nos2 protein, mouse
• Ptgs2 protein, mouse
• Cyclooxygenase 2
• Choline O-Acetyltransferase

Topics

• Alzheimer Disease (drug therapy, metabolism, physiopathology)
• Amyloid beta-Peptides
• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Avoidance Learning (drug effects)
• Behavior, Animal (drug effects)
• Benzofurans (pharmacology, therapeutic use)
• Brain-Derived Neurotrophic Factor (metabolism)
• Choline O-Acetyltransferase (metabolism)
• Cognition Disorders (drug therapy, metabolism, physiopathology)
• Cyclooxygenase 2 (metabolism)
• Disease Models, Animal
• Hippocampus (cytology, drug effects, metabolism)
• Lipid Peroxidation (drug effects)
• Male
• Mice
• Mice, Inbred ICR
• Neuroglia (drug effects, metabolism)
• Neuroprotective Agents (pharmacology, therapeutic use)
• Nitric Oxide Synthase Type II (metabolism)
• Peptide Fragments