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Nasolacrimal system obstruction, ptosis and esotropia due to chemotherapy in acute lymphoblastic leukemia.

Abstract
Eight-year-old girl was admitted to our clinic with the complaint of constant epiphora in the right eye. It was reported that this complaint began after the start of chemotherapy with a diagnosis of Acute Lymphoblastic Leukemia (ALL) about 5 years ago. In addition, eyelid ptosis associated with esotropia also occurred during that period. We found that nasolacrimal duct obstruction did not improve with medical treatment but ptosis and esotropia improved with pyridoxine and pyridostigmine treatment during that period. Examination of the eye on admission revealed nasolacrimal duct obstruction on the right side. Other ocular findings were normal. Nasolacrimal system obstruction, ptosis and esotropia combination has not been reported previously in patients using systemic drugs or receiving chemotherapy due to ALL.
AuthorsOktay Esmer, Remzi Karadag, Erkan Soylu, Ahmet Faik Oner, Evren Burakgazi-Dalkilic
JournalCutaneous and ocular toxicology (Cutan Ocul Toxicol) Vol. 32 Issue 4 Pg. 330-2 (Oct 2013) ISSN: 1556-9535 [Electronic] England
PMID23461596 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Vincristine
  • Prednisolone
  • Asparaginase
  • Methotrexate
  • Daunorubicin
Topics
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects)
  • Asparaginase (administration & dosage)
  • Blepharoptosis (chemically induced)
  • Child
  • Daunorubicin (administration & dosage)
  • Esotropia (chemically induced)
  • Female
  • Humans
  • Lacrimal Duct Obstruction (chemically induced)
  • Methotrexate (administration & dosage)
  • Nasolacrimal Duct
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy)
  • Prednisolone (administration & dosage)
  • Vincristine (administration & dosage)

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